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Differences in nasal immunoglobulin A responses to influenza vaccine strains after live attenuated influenza vaccine (LAIV) immunization in children
- Source :
- Clinical and Experimental Immunology
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- Summary Different vaccine strains included in the live attenuated influenza vaccine (LAIV) have variable efficacy. The reasons for this are not clear and may include differences in immunogenicity. We report a Phase IV open‐label study on the immunogenicity of a single dose of quadrivalent LAIV (Fluenz™ Tetra) in children during the 2015/16 season, to investigate the antibody responses to different strains. Eligible children were enrolled to receive LAIV; nasal samples were collected before and approximately 4 weeks after immunization. There was a significant increase in nasal immunoglobulin (Ig)A to the H3N2, B/Victoria lineage (B/Brisbane) and B/Yamagata lineage (B/Phuket) components, but not to the H1N1 component. The fold change in nasal IgA response was inversely proportional to the baseline nasal IgA titre for H1N1, H3N2 and B/Brisbane. We investigated possible associations that may explain baseline nasal IgA, including age and prior vaccination status, but found different patterns for different antigens, suggesting that the response is multi‐factorial. Overall, we observed differences in immune responses to different viral strains included in the vaccine; the reasons for this require further investigation.<br />Different vaccine strains included in the Live Attenuated Influenza Vaccine (LAIV) have variable efficacy. We performed an immunogenicity study of quadrivalent LAIV in children during the 2015/16 season. There was a significant increase in nasal IgA to the H3N2, B/Victoria lineage (B/Brisbane), and B/Yamagata lineage (B/Phuket) components, but not to the H1N1 component.
- Subjects :
- Male
0301 basic medicine
Immunoglobulin A
nasal
Antibodies, Viral
Editors' Choice
Influenza A Virus, H1N1 Subtype
0302 clinical medicine
vaccine
Immunology and Allergy
Live attenuated influenza vaccine
Medicine
PROTECTION
Child
biology
Immunogenicity
public health
TRIVALENT
3. Good health
Influenza Vaccines
1107 Immunology
Child, Preschool
Original Article
Female
Nasal Cavity
Antibody
influenza
Life Sciences & Biomedicine
Vaccines, Live, Unattenuated
Adolescent
Influenza vaccine
VIRUSES
Immunology
UNITED-STATES
SEASONAL INFLUENZA
03 medical and health sciences
Immune system
children
Antigen
Humans
IGA
Science & Technology
business.industry
Influenza A Virus, H3N2 Subtype
030104 developmental biology
Immunization
biology.protein
business
030215 immunology
Subjects
Details
- ISSN :
- 13652249 and 00099104
- Volume :
- 199
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Immunology
- Accession number :
- edsair.doi.dedup.....2fc50cb60b565551a21366e34aa06d92