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Association Between Atrial Fibrillation and Sudden Cardiac Death
- Source :
- Circulation Research. 127:301-309
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- Emerging evidence suggests that atrial fibrillation (AF) may be associated with an increased risk of sudden cardiac death (SCD). However, AF shares risk factors with numerous cardiac conditions, including coronary heart disease and heart failure—the 2 most common substrates for SCD—making the AF-SCD relationship particularly challenging to address. A careful consideration of confounding factors is essential, since interventions for AF will be effective in reducing SCD only if there is a causal association between these 2 conditions. In this translational review, we detail the plausible underlying pathophysiological mechanisms through which AF may promote or lead to SCD, as well as the existing epidemiological evidence supporting an association between AF and SCD. While the role of AF in predicting SCD in the general population appears limited and not established, AF might be integrated to improve risk stratification in some specific phenotypes. Optimal AF management, including that of its associated conditions, appears to be of interest to prevent AF-related SCD, especially because the AF-SCD relationship is in part driven by heart failure.
- Subjects :
- congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Physiology
Population
030204 cardiovascular system & hematology
Sudden cardiac death
03 medical and health sciences
0302 clinical medicine
hemic and lymphatic diseases
Internal medicine
Atrial Fibrillation
Epidemiology
medicine
Humans
cardiovascular diseases
030212 general & internal medicine
education
education.field_of_study
business.industry
Confounding
Atrial fibrillation
medicine.disease
Pathophysiology
Death, Sudden, Cardiac
Heart failure
Ventricular fibrillation
Cardiology
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15244571 and 00097330
- Volume :
- 127
- Database :
- OpenAIRE
- Journal :
- Circulation Research
- Accession number :
- edsair.doi.dedup.....2fc41bdfc6e886997be2a44af6e6f9a4