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Methods for Intracellular Delivery of Quantum Dots
- Source :
- Topics in Current Chemistry. 379
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Quantum dots (QDs) have attracted considerable attention as fluorescent probes for life sciences. The advantages of using QDs in fluorescence-based studies include high brilliance, a narrow emission band allowing multicolor labeling, a chemically active surface for conjugation, and especially, high photostability. Despite these advantageous features, the size of the QDs prevents their free transport across the plasma membrane, limiting their use for specific labeling of intracellular structures. Over the years, various methods have been evaluated to overcome this issue to explore the full potential of the QDs. Thus, in this review, we focused our attention on physical and biochemical QD delivery methods—electroporation, microinjection, cell-penetrating peptides, molecular coatings, and liposomes—discussing the benefits and drawbacks of each strategy, as well as presenting recent studies in the field. We hope that this review can be a useful reference source for researches that already work or intend to work in this area. Graphic Abstract: Strategies for the intracellular delivery of quantum dots discussed in this review (electroporation, microinjection, cell-penetrating peptides, molecular coatings, and liposomes).[Figure not available: see fulltext.]
- Subjects :
- Chemistry
Electroporation
Cell-penetrating peptides
Nanotechnology
General Chemistry
Limiting
equipment and supplies
010402 general chemistry
Intracellular labeling
01 natural sciences
Microinjection
0104 chemical sciences
Emission band
Quantum dot
Liposomes
Semiconductor nanocrystals
Intracellular
Subjects
Details
- ISSN :
- 23648961 and 23650869
- Volume :
- 379
- Database :
- OpenAIRE
- Journal :
- Topics in Current Chemistry
- Accession number :
- edsair.doi.dedup.....2facfb3db0d25378cf7026ccf082f19a