Back to Search
Start Over
Cytokines and Chemokines in Mycobacterium tuberculosis Infection
- Source :
- Tuberculosis and the Tubercle Bacillus
- Publication Year :
- 2016
-
Abstract
- Chemokines and cytokines are critical for initiating and coordinating the organized and sequential recruitment and activation of cells into Mycobacterium tuberculosis -infected lungs. Correct mononuclear cellular recruitment and localization are essential to ensure control of bacterial growth without the development of diffuse and damaging granulocytic inflammation. An important block to our understanding of TB pathogenesis lies in dissecting the critical aspects of the cytokine/chemokine interplay in light of the conditional role these molecules play throughout infection and disease development. Much of the data highlighted in this review appears at first glance to be contradictory, but it is the balance between the cytokines and chemokines that is critical, and the “goldilocks” (not too much and not too little) phenomenon is paramount in any discussion of the role of these molecules in TB. Determination of how the key chemokines/cytokines and their receptors are balanced and how the loss of that balance can promote disease is vital to understanding TB pathogenesis and to identifying novel therapies for effective eradication of this disease.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Chemokine
Physiology
medicine.medical_treatment
Inflammation
Disease
Biology
Article
Proinflammatory cytokine
Mycobacterium tuberculosis
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Genetics
medicine
Animals
Humans
Tuberculosis
General Immunology and Microbiology
Ecology
Cell Biology
biology.organism_classification
030104 developmental biology
Infectious Diseases
Cytokine
Immunology
biology.protein
Cytokines
Tumor necrosis factor alpha
medicine.symptom
Chemokines
030215 immunology
Subjects
Details
- ISSN :
- 21650497
- Volume :
- 4
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Microbiology spectrum
- Accession number :
- edsair.doi.dedup.....2fac6542ea2e5a47ad1b7bd222c916e2