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Studies on acute human infections using FTIR microspectroscopy and cluster analysis
- Source :
- Biopolymers. 73(4)
- Publication Year :
- 2004
-
Abstract
- A novel methodology for the diagnosis of acute infections using FTIR microspectroscopy (FTIR-MSP) data on blood components and cluster analysis is presented. Blood samples were collected from 11 patients suffering from various infections and 16 age-matched healthy human controls. Blood components such as white blood cells, red blood cells, and plasma were isolated using standard procedures and FTIR-MSP of these components was utilized. A cluster analysis of the FTIR spectra was performed. The spectra obtained from the three blood components of patients were different from those of controls. The FTIR spectra of white blood cells from patients suffering infections were significantly different from the controls. Cluster analyses of averaged FTIR-MSP spectra of white blood cells provided 100% classification between patients and healthy controls.
- Subjects :
- Erythrocytes
Biophysics
Analytical chemistry
Disease cluster
Infections
Biochemistry
Biomaterials
Ftir spectra
Plasma
stomatognathic system
Spectroscopy, Fourier Transform Infrared
Leukocytes
Cluster Analysis
Humans
Fourier transform infrared spectroscopy
Israel
Child
Chromatography
Chemistry
Organic Chemistry
technology, industry, and agriculture
Reproducibility of Results
General Medicine
Case-Control Studies
Microspectrophotometry
Acute Disease
lipids (amino acids, peptides, and proteins)
Subjects
Details
- ISSN :
- 00063525
- Volume :
- 73
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Biopolymers
- Accession number :
- edsair.doi.dedup.....2faa843bfca20addd727725d8f0eeda2