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Serum lipids, lipoprotein analysis and apoprotein A-I, A-II and B levels in Friedreich's ataxia
- Source :
- Scopus-Elsevier, Europe PubMed Central
-
Abstract
- Serum lipid, lipoprotein and apoprotein parameters were evaluated in 15 patients (7 males and 8 females) with Friedreich’s ataxia. Serum lipid levels in patients showed no significant differences compared to controls. Small reduction in serum phospholipid and in total HDL and HDL3 cholesterol levels were observed, and the female patients presented a slight reduced total cholesterol level; among the serum apoproteins, apo B was reduced only in the males. The most interesting findings concerned the lipoproteins, since both lipid and protein masses of the VLDL, LDL and HDL2 fractions were reduced. In reference to lipoprotein composition, however, HDL2 was the most modified fraction, showing an important protein reduction. From this point of view, this lipoprotein seems the most responsible for the changes observed in our patients. The meaning of this modified lipoprotein pattern in the pathophysiology of Friedreich’s ataxia is not clear.
- Subjects :
- Adult
Male
medicine.medical_specialty
Very low-density lipoprotein
Ataxia
Apolipoprotein B
Adolescent
Lipoproteins
Blood lipids
Friedreich’s ataxia
chemistry.chemical_compound
Apoproteins
Lipids
Internal medicine
medicine
Humans
Child
Apolipoproteins A
Apolipoproteins B
biology
Cholesterol
Pathophysiology
Endocrinology
Neurology
chemistry
Friedreich Ataxia
biology.protein
lipids (amino acids, peptides, and proteins)
Apoprotein(a)
Female
Neurology (clinical)
medicine.symptom
Lipoprotein
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier, Europe PubMed Central
- Accession number :
- edsair.doi.dedup.....2fa61c2881e2c7ee51be4bcd0d4a9730