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Alcohol drinking frequency is more directly associated with alcohol use disorder than alcohol metabolizing enzymes among male Japanese
- Source :
- Psychiatry and clinical neurosciences. 59(1)
- Publication Year :
- 2005
-
Abstract
- The development of alcohol use disorder (AUD) is related to various social, economic, cultural, environmental and hereditary factors. Several potential risk factors have been proposed for AUD in addition to alcohol consumption, including alcohol dehydrogenase2 (ADH2), acetaldehyde dehydrogenase2 (ALDH2), marital status, educational, occupational or past medical history (e.g. diabetes mellitus, hypertension, lung, digestive tract, or chronic liver disease) or smoking habits. The present study was performed to investigate the relationship between the aforementioned potential risk factors and AUD in Japan. A case-control study was performed on 153 male Japanese AUD patients and age-, gender-, or other confounder-matched controls to investigate the relation multivariately between ADH2, ALDH2 or alcohol drinking and AUD. Genomic DNA were extracted from nail clippings by the guanidium method, and genotyping of ADH2 and ALDH2 were performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods. Univariate analyses by the conditional logistic regression model revealed statistically significant odds ratios due to ADH2*1/1 genotype, ALDH2*1/1 genotype, middle school as the final school attended, longest occupations as farmers, fishermen, craftsmen, miners, production process or construction workers, and past histories of chronic liver disease and AUD. However, multivariate analyses under a hierarchically well-formulated model strategy with interaction and confounding assessment indicated that (i) heavy alcohol intake was a significant risk factor (odds ratio per 1.0 g of daily ethanol intake; 1.096, 95% confidence interval; 1.026-1.171) for developing AUD after adjusting for other confounders; and (ii) ADH2*1/1 genotype and ALDH2*1/1 genotype were not risk factors after adjusting for daily ethanol intake and other confounders. The present study shows that AUD was more directly and strongly associated with alcohol drinking than with alcohol metabolizing enzymes among male Japanese.
- Subjects :
- Adult
Male
medicine.medical_specialty
Alcohol Drinking
Genotype
Cross-sectional study
Statistics as Topic
Poison control
Alcohol use disorder
Polymerase Chain Reaction
Japan
Risk Factors
Environmental health
mental disorders
medicine
Humans
Aged
business.industry
General Neuroscience
Aldehyde Dehydrogenase, Mitochondrial
Confounding
Case-control study
Alcohol Dehydrogenase
General Medicine
Odds ratio
Aldehyde Dehydrogenase
Middle Aged
medicine.disease
Surgery
Psychiatry and Mental health
Alcoholism
Cross-Sectional Studies
Neurology
Case-Control Studies
Marital status
Neurology (clinical)
business
Polymorphism, Restriction Fragment Length
Subjects
Details
- ISSN :
- 13231316
- Volume :
- 59
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Psychiatry and clinical neurosciences
- Accession number :
- edsair.doi.dedup.....2fa22468666bcc46b721ba5a039eecfc