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Bone Effects of Binge Alcohol Drinking Using Prepubescent Pigs as a Model
- Source :
- Alcoholism, Clinical and Experimental Research
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Background Although chronic alcohol consumption in adults is an established risk factor for osteoporotic fractures, there is a huge gap in our knowledge about bone effects of binge drinking in adolescents. The aim of this pilot study was therefore to assess skeletal effects of binge alcohol drinking using prepubescent pigs as a large animal model. Methods Piglets aged 2 months were offered alcohol orally as a mixture of hard liquor and apple juice. Those with the highest propensity to drink alcohol were included in the experiment and received 1.4 g alcohol/kg bodyweight 2 times per week for 2 months (alcohol group); control piglets received apple juice in an identical manner. At the age of 4 months, the animals were euthanized; trabecular and cortical bone samples from the femur, the tibia, the humerus, and the fourth vertebral body harvested during necropsy were assessed by microcomputed tomography and dynamic histomorphometry. In addition, blood chemistry and blood alcohol determinations were performed. Results Blood alcohol levels assessed 1 hour after alcohol administration were 0.99‰ ± 0.15, 1.12‰ ± 0.2, and 1.14‰ ± 0.18 at the ages of 2, 3, and 4 months, respectively. In the alcohol group, serum calcium and phosphate levels were decreased. In the femur, trabecular number and connectivity density were lower in the alcohol than in the control group, and in the humerus and the fourth vertebral bodies, an opposite pattern was seen for trabecular number and connectivity density, respectively. Cortical density was higher in the humerus and trabecular density higher in the tibia of the alcohol group compared to the control group. Cortical porosity was lower in the humerus of the alcohol group. No significant differences were seen for trabecular thickness, trabecular separation, bone volume fraction, and static and dynamic histomorphometric parameters. Conclusions In this pilot study, we have assessed skeletal effects of binge alcohol drinking by using prepubescent pigs as a promising large animal model. Binge drinking has bone effects that are site-specific. However, these data have to be verified in a larger study population.
- Subjects :
- Male
Alcohol Drinking
Bone Microarchitecture
Swine
Medicine (miscellaneous)
Physiology
Binge drinking
030209 endocrinology & metabolism
Alcohol
Toxicology
Bone and Bones
Binge Drinking
Phosphates
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Animals
Medicine
Femur
Tibia
Binge Alcohol Drinking
Ethanol
Behavior, Animal
Pathology, Immunology and Development
business.industry
Phosphorus
Spine
3. Good health
Psychiatry and Mental health
medicine.anatomical_structure
chemistry
Blood chemistry
Population study
Calcium
Original Article
Pigs
Cortical bone
Tomography, X-Ray Computed
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 01456008
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Alcoholism: Clinical and Experimental Research
- Accession number :
- edsair.doi.dedup.....2f9f94d771549cde177aefdb6a78ae7a