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Maternal crack cocaine use in rats leads to depressive- and anxiety-like behavior, memory impairment, and increased seizure susceptibility in the offspring
- Source :
- European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 44
- Publication Year :
- 2020
-
Abstract
- Crack users suffer the effects of cocaine present in the drug and the action of other active compounds from its pyrolysis. An emergent fact is an increase in the number of pregnant crack cocaine users. Studies suggest that crack cocaine and its metabolites cross the placenta, promoting premature birth, fever, irritability, sweating, and seizures in the early months of life. In children, the effects of crack cocaine have been associated with cognitive deficits, difficulty in verbalization, aggressiveness, and depression, besides enhancing the susceptibility to epileptic seizures, including status epilepticus (SE) in adulthood. Therefore, we investigated the effect of maternal exposure to smoke crack cocaine on several behavioral parameters in the offspring during adulthood. A series of behavioral tests and intrahippocampal pilocarpine (H-PILO) microinjection at sub-convulsive and convulsive doses in a rat model demonstrated that exposure to crack cocaine during the embryonic period leads to anxiogenic-like behavior and long-term memory impairment in both genders and promotes depressive-like behavior in the female. Besides, crack cocaine offspring exposed to a sub-convulsive H-PILO dose showed higher susceptibility to SE, increased seizure frequency, and neurodegeneration, while animals that received a convulsive dose of H-PILO displayed no alteration in SE severity. Taken together, our data suggest that crack cocaine exposure during the gestational period leads to an increased predilection for anxiety and depression, long-term memory deficits, and reduction in the threshold for developing epileptic seizures associated with neuronal death, which predispose crack cocaine babies to develop neuropsychological disorders.
- Subjects :
- Male
medicine.medical_specialty
Offspring
Status epilepticus
Anxiety
Irritability
03 medical and health sciences
Epilepsy
Cocaine-Related Disorders
0302 clinical medicine
Status Epilepticus
Pregnancy
Seizures
Internal medicine
medicine
Memory impairment
Animals
Pharmacology (medical)
Biological Psychiatry
Pharmacology
Memory Disorders
business.industry
Pilocarpine
medicine.disease
030227 psychiatry
Rats
Psychiatry and Mental health
Endocrinology
Neurology
Premature birth
Crack Cocaine
Female
Neurology (clinical)
medicine.symptom
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 18737862
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
- Accession number :
- edsair.doi.dedup.....2f923f32f9f223721a29015fece71afc