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Emerging Role of Ubiquitination in the Regulation of PD-1/PD-L1 in Cancer Immunotherapy
- Source :
- Mol Ther
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- A growing amount of evidence suggests that ubiquitination and deubiquitination of programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) play crucial roles in the regulation of PD-1 and PD-L1 protein stabilization and dynamics. PD-1/PD-L1 is a major coinhibitory checkpoint pathway that modulates immune escape in cancer patients, and its engagement and inhibition has significantly reshaped the landscape of tumor clearance. The abnormal ubiquitination and deubiquitination of PD-1/PD-L1 influence PD-1/PD-L1-mediated immunosuppression. In this review, we describe the ubiquitination- and deubiquitination-mediated modulation of PD-1/PD-L1 signaling through a variety of E3 ligases and deubiquitinating enzymes (DUBs). Moreover, we briefly expound on the anticancer potential of some agents that target related E3 ligases, which further modulate the ubiquitination of PD-1/PD-L1 in cancers. Therefore, this review reveals the development of a highly promising therapeutic approach for cancer immunotherapy by targeting PD-1/PD-L1 ubiquitination.
- Subjects :
- medicine.medical_treatment
Programmed Cell Death 1 Receptor
Review
B7-H1 Antigen
Deubiquitinating enzyme
03 medical and health sciences
0302 clinical medicine
Cancer immunotherapy
Ubiquitin
Neoplasms
PD-L1
Drug Discovery
Genetics
medicine
Animals
Humans
Molecular Biology
030304 developmental biology
Pharmacology
0303 health sciences
biology
Ubiquitination
Cancer
Immunotherapy
medicine.disease
030220 oncology & carcinogenesis
biology.protein
Cancer research
Molecular Medicine
Protein stabilization
Deubiquitination
Subjects
Details
- ISSN :
- 15250016
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Molecular Therapy
- Accession number :
- edsair.doi.dedup.....2f874e9c87b5cf8c5baf4426d313f0a6