Back to Search
Start Over
Initial and late prognostic factors to predict survival in adult acute lymphoblastic leukaemia
- Source :
- European Journal of Haematology, European Journal of Haematology, 2006, 77 (6), pp.471-479, European Journal of Haematology, Wiley, 2006, 77 (6), pp.471-479, European Journal of Haematology, 2006, 77, pp.471-479
- Publication Year :
- 2006
- Publisher :
- HAL CCSD, 2006.
-
Abstract
- Factors able to predict overall survival in adult patients with acute lymphoblastic leukaemia were assessed according to the period since initiation of the treatment using a Cox proportional hazards model. This period covers successively an initial period during the induction treatment and a consolidation period during the postinduction treatment. From 1994 to 2002, 922 patients with acute lymphoblastic leukaemia (excluding French-American-British L3 subtype) were enrolled in a multicentre protocol and followed, with a mean follow up of 58 months. A multivariate time-segmented analysis was performed on 658 patients. Analyses of the initial (before 100 d) and the late phases were realised after stratification on the type of induction treatment and on the different treatment strategies respectively. Age was the sole factor that influenced survival during the initial phase (hazard ratio 1.48 per 10-yr increase; P
- Subjects :
- Adult
medicine.medical_specialty
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT]
Adolescent
[SDV]Life Sciences [q-bio]
Lactic dehydrogenase
Gastroenterology
Translocation, Genetic
Immunophenotyping
03 medical and health sciences
0302 clinical medicine
Late phase
Internal medicine
medicine
Overall survival
Humans
030304 developmental biology
Proportional Hazards Models
0303 health sciences
Adult patients
Proportional hazards model
business.industry
Hazard ratio
Age Factors
Hematology
General Medicine
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma
3. Good health
Surgery
Treatment Outcome
030220 oncology & carcinogenesis
Initial phase
Karyotyping
Multivariate Analysis
Lymphoblastic leukaemia
Female
business
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 09024441 and 16000609
- Database :
- OpenAIRE
- Journal :
- European Journal of Haematology, European Journal of Haematology, 2006, 77 (6), pp.471-479, European Journal of Haematology, Wiley, 2006, 77 (6), pp.471-479, European Journal of Haematology, 2006, 77, pp.471-479
- Accession number :
- edsair.doi.dedup.....2f840a673505da846e5d48e9570b8f71