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Establishing the prevalence of common tissue‐specific autoantibodies following severe acute respiratory syndrome coronavirus 2 infection
- Source :
- Clinical and Experimental Immunology
- Publication Year :
- 2021
- Publisher :
- John Wiley and Sons Inc., 2021.
-
Abstract
- Summary Coronavirus 19 (COVID‐19) has been associated with both transient and persistent systemic symptoms that do not appear to be a direct consequence of viral infection. The generation of autoantibodies has been proposed as a mechanism to explain these symptoms. To understand the prevalence of autoantibodies associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, we investigated the frequency and specificity of clinically relevant autoantibodies in 84 individuals previously infected with SARS‐CoV‐2, suffering from COVID‐19 of varying severity in both the acute and convalescent setting. These were compared with results from 32 individuals who were on the intensive therapy unit (ITU) for non‐COVID reasons. We demonstrate a higher frequency of autoantibodies in the COVID‐19 ITU group compared with non‐COVID‐19 ITU disease control patients and that autoantibodies were also found in the serum 3–5 months post‐COVID‐19 infection. Non‐COVID patients displayed a diverse pattern of autoantibodies; in contrast, the COVID‐19 groups had a more restricted panel of autoantibodies including skin, skeletal muscle and cardiac antibodies. Our results demonstrate that respiratory viral infection with SARS‐CoV‐2 is associated with the detection of a limited profile of tissue‐specific autoantibodies, detectable using routine clinical immunology assays. Further studies are required to determine whether these autoantibodies are specific to SARS‐CoV‐2 or a phenomenon arising from severe viral infections and to determine the clinical significance of these autoantibodies.<br />Acute infection with COVID is associated with a pattern of autoantibodies including a high proportion with epidermal antibodies. This autoantibody pattern is more common in severe COVID and is persistent up to 6 months.
- Subjects :
- 0301 basic medicine
Adult
Male
autoantibodies
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Immunology
medicine.disease_cause
Severity of Illness Index
SARS‐CoV‐2
Autoimmunity
03 medical and health sciences
Editors' Choice
0302 clinical medicine
COVID‐19
Antibody Specificity
Severity of illness
medicine
Immunology and Allergy
Humans
Clinical significance
long COVID
Coronavirus
Aged
biology
business.industry
SARS-CoV-2
autoimmunity
Autoantibody
COVID-19
Middle Aged
030104 developmental biology
Organ Specificity
biology.protein
Original Article
Female
Antibody
business
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 13652249 and 00099104
- Volume :
- 205
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Immunology
- Accession number :
- edsair.doi.dedup.....2f8323bf5b8a586dad3760767d499bc8