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Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
- Source :
- PLoS Genetics, Vol 16, Iss 10, p e1008718 (2020), PLoS Genetics, Addi. Archivo Digital para la Docencia y la Investigación, instname, Vogelezang, S, Bradfield, J P, Ahluwalia, T S, Curtin, J A, Grarup, N, Schnurr, T M, Hansen, T, Michaelsen, K F, Pedersen, O B, Stokholm, J, Lind, M V, Frithioff-Bøjsøe, C, Holm, J-C, Felix, J F & Early Growth Genetics Consortium 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', P L o S Genetics, vol. 16, no. 10, e1008718 . https://doi.org/10.1371/journal.pgen.1008718, Vogelezang, S, Bradfield, J P, Ahluwalia, T S, Curtin, J A, Lakka, T A, Grarup, N, Scholz, M, van der Most, P J, Monnereau, C, Stergiakouli, E, Heiskala, A, Horikoshi, M, Fedko, I O, Vilor-Tejedor, N, Cousminer, D L, Standl, M, Wang, C A, Viikari, J, Geller, F, Íñiguez, C, Pitkänen, N, Chesi, A, Bacelis, J, Yengo, L, Torrent, M, Ntalla, I, Helgeland, Ø, Selzam, S, Vonk, J M, Zafarmand, M H, Heude, B, Farooqi, I S, Alyass, A, Beaumont, R N, Have, C T, Rzehak, P, Bilbao, J R, Schnurr, T M, Barroso, I, Bønnelykke, K, Beilin, L J, Carstensen, L, Charles, M A, Chawes, B, Clément, K, Closa-Monasterolo, R, Custovic, A, Hansen, T, Morgen, C S, Nohr, E A & Early Growth Genetics Consortium 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', PLOS Genetics, vol. 16, no. 10, e1008718 . https://doi.org/10.1371/journal.pgen.1008718, PLOS Genetics, PLoS Genetics (online), 16(10):e1008718. Public Library of Science, PLoS genetics, 16(10):e1008718. Public Library of Science, PLoS Genetics, Public Library of Science, 2020, 16 (10), pp.e1008718. ⟨10.1371/journal.pgen.1008718⟩, e1008718, PLOS GENETICS, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Fedko, I O, Groen-Blokhuis, M, Hottenga, J-J, Van Beijsterveldt, C E M, Vrijkotte, T G M, Boomsma, D I & Early Growth Genetics (EGG) Consortium 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', PLoS Genetics, vol. 16, no. 10, e1008718, pp. 1-26 . https://doi.org/10.1371/journal.pgen.1008718, PLoS Genetics, 2020, 16 (10), pp.e1008718. ⟨10.1371/journal.pgen.1008718⟩, PLoS Genetics, 16(10):e1008718, 1-26. Public Library of Science, Addi: Archivo Digital para la Docencia y la Investigación, Universidad del País Vasco, r-FISABIO. Repositorio Institucional de Producción Científica, Curtin, J, Murray, C & et al. 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', PL o S Genetics . https://doi.org/10.1371/journal.pgen.1008718, PLoS genetics, 16(10):e1008718. PUBLIC LIBRARY SCIENCE, PLoS Genet. 16:e1008718 (2020)
- Publication Year :
- 2020
- Publisher :
- PUBLIC LIBRARY SCIENCE, 2020.
-
Abstract
- The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located nearNEDD4LandSLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (R(g)ranging from 0.11 to 0.76, P-values<br />CP received funding from the National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London. MMcC is a Wellcome Senior Investigator and an NIHR Senior Investigator. MMcC received funding from Wellcome (090532, 106130, 098381, 203141, 212259), NIDDK (U01DK105535), and NIHR (NF-SI-0617-10090). TGMV was supported by ZonMW (TOP 40-00812-9811010). DLC was supported by the American Diabetes Association Grant 1-17-PDF-077. SFAG is supported by the Daniel B. Burke Chair for Diabetes Research and NIH Grant R01 HD058886. NVT is funded by a pre-doctoral grant from the Agencia de Gestio d'Ajuts Universitaris i de Recerca (2017 FI_B 00636), Generalitat de Catalunya -Fons Social Europeu. BK received personal funding from the European Research Council Advanced Grant META-GROWTH (ERC-2012-AdG -no. 322605). BF was supported by an Oak Foundation Fellowship. RMF and RNB are supported by Sir Henry Dale Fellowship (Wellcome Trust and Royal Society grant: WT104150). ATH is supported by a Wellcome Trust Senior Investigator award (grant number 098395/Z/12/Z). DM is supported by a Canada Research Chair. DLC was supported by the American Diabetes Association Grant 1-17-PDF077. JTL was supported by the Finnish Cultural Foundation. DIB received a KNAW Academy Professor Award (PAH/6635). MH received PhD scholarship funding from TARGET (http://target.ku.dk), The Danish Diabetes Academy (http://danishdiabetesacademy.dk) and the Copenhagen Graduate School of Health and Medical Sciences. VWVJ received funding from the Netherlands Organization for Health Research and Development (VIDI 016.136.361) and the European Research Council (ERC-2014-CoG-648916). ISF was supported by the European Research Council, Wellcome Trust (098497/Z/12/Z), Medical Research Council (MRC_MC_UU_12012/5), the NIHR Cambridge Biomedical Research Centre, the Botnar Foundation, the Bernard Wolfe Health Neuroscience Endowment and the European Community's Seventh Framework Programme (FP7/2007-2013) project Beta-JUDO n degrees 279153. IB acknowledges funding from Wellcome (WT206194). ES works in a unit that receives funding from the University of Bristol and the UK Medical Research Council (MC_UU_00011/1, MC_UU_00011/3). GDS works in the Medical Research Council Integrative Epidemiology Unit at the University of Bristol, which is supported by the Medical Research Council (MC_UU_00011/1). KC received funds from the French National Agency of Research, F-CRIN/FORCE. All funding for the studies that provided the underlying data for this manuscript can be found in S1 Text. The funders had no role in study design, data collection and analysis, data interpretation, decision to publish, or preparation of the manuscript.
- Subjects :
- Male
Genetic-variation
Nedd4 Ubiquitin Protein Ligases
Pooled Analysis
Blood Pressure
0302 clinical medicine
Human genetics
Mendelian Randomization
Young adult
Child
health care economics and organizations
Body mass index
Adiposity
Genetics & Heredity
0303 health sciences
Statistics
1184 Genetics, developmental biology, physiology
Genomics
adulto
3. Good health
Cardiovascular Diseases
Child, Preschool
Physical Sciences
Menarche
genetic-variation
presión sanguínea
Monosaccharide Transport Proteins
Genetic loci
education
enfermedades cardiovasculares
Prostate-specific Antigen
Genetic correlation
03 medical and health sciences
SDG 3 - Good Health and Well-being
Diabetes Mellitus
Genetics
Humans
prostate-specific antigen
Statistical Methods
Molecular Biology
Ecology, Evolution, Behavior and Systematics
childhood
0604 Genetics
[SDV.GEN]Life Sciences [q-bio]/Genetics
Science & Technology
Early Growth Genetics Consortium
Biology and Life Sciences
Computational Biology
nutritional and metabolic diseases
Single nucleotide polymorphisms
Mendelian Randomization Analysis
Biological Tissue
Diabetes Mellitus, Type 2
estudio de asociación genómica completa
genetic factors
mendelian randomization
análisis de la aleatorización mendeliana
proteínas de transporte de monosacáridos
030217 neurology & neurosurgery
Mathematics
Demography
Developmental Biology
Cardiovascular Risk
Cancer Research
obesity
Physiology
humanos
adolescente
Overweight
QH426-470
Genome-wide association studies
Waist–hip ratio
Mathematical and Statistical Techniques
Medicine and Health Sciences
body mass index (BMI)
Genetics of disease
Genetics (clinical)
2. Zero hunger
adiposity
Metaanalysis
Physiological Parameters
Connective Tissue
Female
medicine.symptom
Anatomy
pooled analysis
Life Sciences & Biomedicine
Research Article
Adult
cardiovascular risk
Adolescent
Birth weight
menarquia
Adipose tissue
Biology
3121 Internal medicine
Research and Analysis Methods
medicine
overweight
Genetic Predisposition to Disease
Obesity
030304 developmental biology
Waist-Hip Ratio
índice de masa corporal
Body Weight
Cardiometabolic Risk Factors
predisposición genética a la enfermedad
Heritability
Genome Analysis
young-adults
Genome-wide Association
índice cintura-cadera
Young-adults
genome-wide association
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 15537404 and 15537390
- Volume :
- 16
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS genetics
- Accession number :
- edsair.doi.dedup.....2f7e3e9c63ac8faa6aa819187732da43