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No Evidence for Disease History as a Risk Factor for Narcolepsy after A(H1N1)pdm09 Vaccination
- Source :
- PLoS ONE, Vol 11, Iss 4, p e0154296 (2016), PLoS ONE, PLoS One (print), 11(4):e0154296. Public Library of Science
- Publication Year :
- 2016
- Publisher :
- Public Library of Science (PLoS), 2016.
-
Abstract
- Objectives To investigate disease history before A(H1N1)pdm09 vaccination as a risk factor for narcolepsy. Methods Case-control study in Sweden. Cases included persons referred for a Multiple Sleep Latency Test between 2009 and 2010, identified through diagnostic sleep centres and confirmed through independent review of medical charts. Controls, selected from the total population register, were matched to cases on age, gender, MSLT-referral date and county of residence. Disease history (prescriptions and diagnoses) and vaccination history was collected through telephone interviews and population-based healthcare registers. Conditional logistic regression was used to investigate disease history before A(H1N1)pdm09 vaccination as a risk-factor for narcolepsy. Results In total, 72 narcolepsy cases and 251 controls were included (range 3–69 years mean19-years). Risk of narcolepsy was increased in individuals with a disease history of nervous system disorders (OR range = 3.6–8.8) and mental and behavioural disorders (OR = 3.8, 95% CI 1.6–8.8) before referral. In a second analysis of vaccinated individuals only, nearly all initial associations were no longer statistically significant and effect sizes were smaller (OR range = 1.3–2.6). A significant effect for antibiotics (OR = 0.4, 95% CI 0.2–0.8) and a marginally significant effect for nervous system disorders was observed. In a third case-only analysis, comparing cases referred before vaccination to those referred after; prescriptions for nervous system disorders (OR = 26.0 95% CI 4.0–170.2) and ADHD (OR = 35.3 95% CI 3.4–369.9) were statistically significant during the vaccination period, suggesting initial associations were due to confounding by indication. Conclusion The findings of this study do not support disease history before A(H1N1)pdm09 vaccination as a risk factor for narcolepsy.
- Subjects :
- 0301 basic medicine
Male
Central Nervous System
Bacterial Diseases
Pediatrics
genetic structures
Pulmonology
viruses
lcsh:Medicine
Disease
Nervous System
0302 clinical medicine
Influenza A Virus, H1N1 Subtype
Risk Factors
Odds Ratio
Medicine and Health Sciences
Public and Occupational Health
Registries
Child
lcsh:Science
Multidisciplinary
Vaccination
virus diseases
Middle Aged
A h1n1 pdm09
Vaccination and Immunization
Infectious Diseases
Neurology
Influenza Vaccines
Child, Preschool
Female
Anatomy
Research Article
Adult
medicine.medical_specialty
Adolescent
Immunology
Neuropsychiatric Disorders
03 medical and health sciences
Developmental Neuroscience
SDG 3 - Good Health and Well-being
Influenza, Human
Mental Health and Psychiatry
medicine
Humans
Risk factor
Aged
Narcolepsy
Sweden
business.industry
lcsh:R
Case-control study
Biology and Life Sciences
Health Risk Analysis
Odds ratio
medicine.disease
Dyssomnias
respiratory tract diseases
Health Care
030104 developmental biology
Logistic Models
Neurodevelopmental Disorders
Case-Control Studies
Respiratory Infections
Adhd
lcsh:Q
Preventive Medicine
Nervous System Diseases
business
Sleep Disorders
030217 neurology & neurosurgery
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....2f7b2e6742ad496dec6667ef559fceaa