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Neuroanatomical correlates of childhood apraxia of speech: A connectomic approach
- Source :
- NeuroImage : Clinical, NeuroImage: Clinical, Vol 12, Iss C, Pp 894-901 (2016)
- Publication Year :
- 2016
-
Abstract
- Childhood apraxia of speech (CAS) is a paediatric speech sound disorder in which precision and consistency of speech movements are impaired. Most children with idiopathic CAS have normal structural brain MRI. We hypothesize that children with CAS have altered structural connectivity in speech/language networks compared to controls and that these altered connections are related to functional speech/language measures. Whole brain probabilistic tractography, using constrained spherical deconvolution, was performed for connectome generation in 17 children with CAS and 10 age-matched controls. Fractional anisotropy (FA) was used as a measure of connectivity and the connections with altered FA between CAS and controls were identified. Further, the relationship between altered FA and speech/language scores was determined. Three intra-hemispheric/interhemispheric subnetworks showed reduction of FA in CAS compared to controls, including left inferior (opercular part) and superior (dorsolateral, medial and orbital part) frontal gyrus, left superior and middle temporal gyrus and left post-central gyrus (subnetwork 1); right supplementary motor area, left middle and inferior (orbital part) frontal gyrus, left precuneus and cuneus, right superior occipital gyrus and right cerebellum (subnetwork 2); right angular gyrus, right superior temporal gyrus and right inferior occipital gyrus (subnetwork 3). Reduced FA of some connections correlated with diadochokinesis, oromotor skills, expressive grammar and poor lexical production in CAS. These findings provide evidence of structural connectivity anomalies in children with CAS across specific brain regions involved in speech/language function. We propose altered connectivity as a possible epiphenomenon of complex pathogenic mechanisms in CAS which need further investigation.<br />Highlights • Connectivity anomalies are present in children with Childhood Apraxia of Speech. • Connectivity anomalies include brain regions involved in speech/language function. • Altered connectivity correlates with a measure of speech/language dysfunction.
- Subjects :
- Apraxias
Middle temporal gyrus
Cognitive Neuroscience
lcsh:Computer applications to medicine. Medical informatics
050105 experimental psychology
lcsh:RC346-429
Speech Disorders
Cuneus
Childhood apraxia of speech
03 medical and health sciences
0302 clinical medicine
Gyrus
Nuclear Medicine and Imaging
Fractional anisotropy
medicine
Connectome
Humans
0501 psychology and cognitive sciences
Radiology, Nuclear Medicine and imaging
Language Development Disorders
lcsh:Neurology. Diseases of the nervous system
Cerebral Cortex
Connectivity
Diadochokinesis
05 social sciences
Regular Article
Frontal gyrus
medicine.disease
Diffusion magnetic resonance
Radiology, Nuclear Medicine and Imaging
Neurology
Neurology (clinical)
medicine.anatomical_structure
Diffusion Tensor Imaging
Child, Preschool
Speech sound disorder
lcsh:R858-859.7
Psychology
Radiology
Neuroscience
030217 neurology & neurosurgery
Cognitive psychology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- NeuroImage : Clinical, NeuroImage: Clinical, Vol 12, Iss C, Pp 894-901 (2016)
- Accession number :
- edsair.doi.dedup.....2f79be5488fecf80df77886ffebf2db8