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Developmental evolution and developmental plasticity of the olfactory epithelium and olfactory skills in Mexican cavefish
- Source :
- Developmental Biology, Developmental Biology, Elsevier, 2018, ⟨10.1016/j.ydbio.2018.04.019⟩
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- International audience; The fish Astyanax mexicanus comes in two forms: the normal surface-dwelling (SF) and the blind depigmented cave-adapted (CF) morphs. Among many phenotypic differences, cavefish show enhanced olfactory sensitivity to detect amino-acid odors and they possess large olfactory sensory organs. Here, we questioned the relationship between the size of the olfactory organ and olfactory capacities. Comparing olfactory detection abilities of CF, SF and F1 hybrids with various olfactory epithelium (OE) sizes in behavioral tests, we concluded that OE size is not the only factor involved. Other possibilities were envisaged. First, olfactory behavior was tested in SF raised in the dark or after embryonic lens ablation, which leads to eye degeneration and mimics the CF condition. Both absence of visual function and absence of visual organs improved the SF olfactory detection capacities, without affecting the size of their OE. This suggested that developmental plasticity occurs between the visual and the olfactory modalities, and can be recruited in SF after visual deprivation. Second, the development of the olfactory epithelium was compared in SF and CF in their first month of life. Proliferation, cell death, neuronal lifespan, and olfactory progenitor cell cycling properties were identical in the two morphs. By contrast, the proportions of the three main olfactory sensory neurons subtypes (ciliated, microvillous and crypt) in their OE differed. OMP-positive ciliated neurons were more represented in SF, TRPC2-positive microvillous neurons were proportionately more abundant in CF, and S100-positive crypt cells were found in equal densities in the two morphs. Thus, general proliferative properties of olfactory progenitors are identical but neurogenic properties differ and lead to variations in the neuronal composition of the OE in SF and CF. Together, these experiments suggest that there are at least two components in the evolution of cavefish olfactory skills: (1) one part of eye-dependent developmental phenotypic plasticity, which does not depend on the size of the olfactory organ, and (2) one part of developmental evolution of the OE, which may stem from embryonic specification of olfactory neurons progenitor pools.
- Subjects :
- 0301 basic medicine
Olfactory system
Neurogenesis
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Proliferation
Cavefish
Sensory system
Olfaction
Biology
Olfactory sensory neuron
03 medical and health sciences
0302 clinical medicine
Neural Stem Cells
Olfactory Mucosa
medicine
Animals
Molecular Biology
Cell Proliferation
Phenotypic plasticity
Behavior, Animal
Cell Death
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
Cell Biology
Olfactory Perception
Cell biology
Smell
030104 developmental biology
medicine.anatomical_structure
Developmental plasticity
Characiformes
Organ size
Olfactory epithelium
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 00121606 and 1095564X
- Database :
- OpenAIRE
- Journal :
- Developmental Biology, Developmental Biology, Elsevier, 2018, ⟨10.1016/j.ydbio.2018.04.019⟩
- Accession number :
- edsair.doi.dedup.....2f64eadd6cb30c9db31eacee41b5dde7