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Aerosol generation during chest compression and defibrillation in a swine cardiac arrest model
- Source :
- Resuscitation
- Publication Year :
- 2020
-
Abstract
- Aim It remains unclear whether cardiac arrest (CA) resuscitation generates aerosols that can transmit respiratory pathogens. We hypothesize that chest compression and defibrillation generate aerosols that could contain the SARS-CoV-2 virus in a swine CA model. Methods To simulate witnessed CA with bystander-initiated cardiopulmonary resuscitation, 3 female non-intubated swine underwent 4 min of ventricular fibrillation without chest compression or defibrillation (no-flow) followed by ten 2-min cycles of mechanical chest compression and defibrillation without ventilation. The diameter (0.3–10 μm) and quantity of aerosols generated during 45-s intervals of no-flow and chest compression before and after defibrillation were analyzed by a particle analyzer. Aerosols generated from the coughs of 4 healthy human subjects were also compared to aerosols generated by swine. Results There was no significant difference between the total aerosols generated during chest compression before defibrillation compared to no-flow. In contrast, chest compression after defibrillation generated significantly more aerosols than chest compression before defibrillation or no-flow (72.4 ± 41.6 × 104 vs 12.3 ± 8.3 × 104 vs 10.5 ± 11.2 × 104; p
- Subjects :
- medicine.medical_specialty
Resuscitation
Defibrillation
Swine
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
medicine.medical_treatment
Pilot Projects
Heart Massage
030204 cardiovascular system & hematology
Emergency Nursing
Swine model
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Animals
Humans
Cardiopulmonary resuscitation
Aerosols
Aerosol generation
business.industry
SARS-CoV-2
COVID-19
030208 emergency & critical care medicine
respiratory system
Compression (physics)
medicine.disease
Cardiac arrest
Aerosol
Emergency
Ventricular fibrillation
Emergency Medicine
Breathing
Cardiology
Female
Chest compression
Cardiology and Cardiovascular Medicine
business
Out-of-Hospital Cardiac Arrest
Experimental Paper
Subjects
Details
- ISSN :
- 18731570
- Volume :
- 159
- Database :
- OpenAIRE
- Journal :
- Resuscitation
- Accession number :
- edsair.doi.dedup.....2f630b1803c2159d28f09c9970b8a01c