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The Admixture Structure and Genetic Variation of the Archipelago of Cape Verde and Its Implications for Admixture Mapping Studies
- Source :
- PLoS ONE, PLoS ONE, Vol 7, Iss 11, p e51103 (2012)
- Publication Year :
- 2012
- Publisher :
- Public Library of Science, 2012.
-
Abstract
- Recently admixed populations offer unique opportunities for studying human history and for elucidating the genetic basis of complex traits that differ in prevalence between human populations. Historical records, classical protein markers, and preliminary genetic data indicate that the Cape Verde islands in West Africa are highly admixed and primarily descended from European males and African females. However, little is known about the variation in admixture levels, admixture dynamics and genetic diversity across the islands, or about the potential of Cape Verde for admixture mapping studies. We have performed a detailed analysis of phenotypic and genetic variation in Cape Verde based on objective skin color measurements, socio-economic status (SES) evaluations and data for 50 autosomal, 34 X-chromosome, and 21 non-recombinant Y-chromosome (NRY) markers in 845 individuals from six islands of the archipelago. We find extensive genetic admixture between European and African ancestral populations (mean West African ancestry = 0.57, sd = 0.08), with individual African ancestry proportions varying considerably among the islands. African ancestry proportions calculated with X and Y-chromosome markers confirm that the pattern of admixture has been sex-biased. The high-resolution NRY-STRs reveal additional patterns of variation among the islands that are most consistent with differentiation after admixture. The differences in the autosomal admixture proportions are clearly evident in the skin color distribution across the islands (Pearson r = 0.54, P-value
- Subjects :
- Evolutionary Genetics
Male
Heredity
Science
Genetic genealogy
Population
Genetic admixture
Population genetics
Skin Pigmentation
Biology
Haplogroup
Cape verde
03 medical and health sciences
Genetic variation
Genetics
Cabo Verde
Humans
education
Genetic Association Studies
Phylogeny
030304 developmental biology
Islands
0303 health sciences
Genetic diversity
education.field_of_study
Evolutionary Biology
Multidisciplinary
Chromosomes, Human, Y
Geography
030305 genetics & heredity
Genetic Variation
Human Genetics
Gene Pool
Phenotypes
Genetics, Population
Haplotypes
Evolutionary biology
Medicine
Regression Analysis
Female
Population Genetics
Research Article
Genealogy and Heraldry
Microsatellite Repeats
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 7
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....2f614e8b83f213b5c0645184efc71fd5