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The Popeye domain containing gene family encoding a family of cAMP-effector proteins with important functions in striated muscle and beyond
- Source :
- Journal of Muscle Research and Cell Motility
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- The Popeye domain containing (POPDC) gene family encodes a novel class of membrane-bound cyclic AMP effector proteins. POPDC proteins are abundantly expressed in cardiac and skeletal muscle. Consistent with its predominant expression in striated muscle, Popdc1 and Popdc2 null mutants in mouse and zebrafish develop cardiac arrhythmia and muscular dystrophy. Likewise, mutations in POPDC genes in patients have been associated with cardiac arrhythmia and muscular dystrophy phenotypes. A membrane trafficking function has been identified in this context. POPDC proteins have also been linked to tumour formation. Here, POPDC1 plays a role as a tumour suppressor by limiting c-Myc and WNT signalling. Currently, a common functional link between POPDC’s role in striated muscle and as a tumour suppressor is lacking. We also discuss several alternative working models to better understand POPDC protein function.
- Subjects :
- 0301 basic medicine
Physiology
CYCLIC-NUCLEOTIDES
Muscle Proteins
Membrane trafficking
0601 Biochemistry and Cell Biology
Second Messenger Systems
Biochemistry
Muscular Dystrophies
Adenylyl cyclase
Mice
chemistry.chemical_compound
0302 clinical medicine
Cyclic AMP
Muscular dystrophy
Popeye domain containing genes
Wnt Signaling Pathway
Zebrafish
biology
Effector
Sinus node disease
Cell biology
medicine.anatomical_structure
Multigene Family
SKELETAL-MUSCLE
HEART
Original Article
Limb-girdle muscular dystrophy
Life Sciences & Biomedicine
Tumour suppressor
Atrioventricular block
EXPRESSION
Context (language use)
POPDC PROTEINS
Proto-Oncogene Proteins c-myc
03 medical and health sciences
cAMP
C-MYC
KINASE
medicine
Animals
Humans
Gene family
Science & Technology
Tumor Suppressor Proteins
ADENYLYL-CYCLASE
Skeletal muscle
Arrhythmias, Cardiac
Cell Biology
0606 Physiology
biology.organism_classification
medicine.disease
Muscle, Striated
030104 developmental biology
chemistry
Mutation
CELLS
BVES
Cell Adhesion Molecules
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15732657 and 01424319
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Journal of Muscle Research and Cell Motility
- Accession number :
- edsair.doi.dedup.....2f60f0dae2835d7d4de005b6d7746141