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Imaging and genetic investigations of neural tube defect in a calf: case report and review of the literature
- Publication Year :
- 2019
- Publisher :
- SAGE Publications, 2019.
-
Abstract
- A 15-d-old female crossbreed calf was referred because of paraplegia since birth. Clinical examination revealed a skin defect covered by hair on the dorsal midline in the thoracic area of the spine. Thoracolumbar spinal cord neuroanatomic localization was determined based on neurologic examination. Computed tomography of the thoracolumbar spine revealed incomplete fusion of the vertebral arches from T6 to T10 and duplication of the vertebral arch of T7. At the level of T6-T7, duplication of the spinal cord with 2 segments completely separated by a septum of hyperattenuating, probably cartilaginous, tissue was noted. Histologically, the spinal segments had different degrees of duplication. Three central canals were detected in one region. Genetic investigation for the presence of methylenetetrahydrofolate reductase (MTHFR) polymorphism, which has been investigated in both human and veterinary medicine as a possible cause of neural tube defects and abortion, was carried out and was negative in both the calf and her dam.
- Subjects :
- 040301 veterinary sciences
Cattle Diseases
Physical examination
Anomaly of nervous system
cattle
diastematomyelia
diplomyelia
Animals
Cattle
Female
Genetic Predisposition to Disease
Neural Tube Defects
Pregnancy
0403 veterinary science
03 medical and health sciences
Gene duplication
medicine
030304 developmental biology
Diastematomyelia
0303 health sciences
General Veterinary
biology
Neural tube defect
medicine.diagnostic_test
business.industry
Neural tube
04 agricultural and veterinary sciences
Anatomy
medicine.disease
Spinal cord
musculoskeletal system
medicine.anatomical_structure
Methylenetetrahydrofolate reductase
biology.protein
business
Paraplegia
Brief Communications
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....2f5187f3adee571b89ff6014514d2b38