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Comparative prognostic value of different preoperative complete blood count cell ratios in patients with oral cavity cancer treated with surgery and postoperative radiotherapy
- Source :
- Cancer Medicine, Vol 10, Iss 6, Pp 1975-1988 (2021), Cancer Medicine
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Background We sought to compare the prognostic significance of different preoperative complete blood count cell ratios in patients with oral cavity squamous cell carcinoma (OSCC) treated with surgery and postoperative radiotherapy (PORT). Methods We retrospectively reviewed the clinical records of 890 patients with OSCC who were treated with surgery and PORT. The following preoperative complete blood count cell ratios were collected: neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and lymphocyte‐to‐monocyte ratio (LMR). Overall survival (OS), local control, regional control, and distant control (DC) served as the main outcomes of interest. Results The results of multivariate analysis in the entire study cohort revealed that a low NLR was the only independently favorable marker of both OS (adjusted hazard ratio [HR]: 0.794, 95% confidence interval (CI): 0.656–0.961, bootstrap p = 0.028) and DC (adjusted HR: 0.659, 95% CI: 0.478–0.909, bootstrap p = 0.015). Both LMR and PLR were not retained in the model as independent predictors. Subgroup analyses in high‐risk patients (i.e., those bearing T4 disease, N3 disease, or poor differentiation) revealed that a high NLR was a significant adverse risk factor for both OS and DC (all p<br />This relatively large cohort reports a comparative result: pretreatment high neutrophil‐to‐lymphocyte ratio (NLR) was an independent unfavorable risk factor for both overall survival and distant metastasis in patients with oral cavity squamous cell carcinoma (OSCC) who underwent surgery and postoperative radiotherapy. Lymphocyte‐to‐monocyte ratio (LMR) and platelet‐to‐lymphocyte ratio (PLR) were not significant.
- Subjects :
- 0301 basic medicine
Male
Cancer Research
Neutrophils
Kaplan-Meier Estimate
Monocytes
oral cavity squamous cell carcinoma
0302 clinical medicine
distant metastasis
platelet‐to‐lymphocyte ratio
Lymphocytes
Original Research
medicine.diagnostic_test
Hazard ratio
Complete blood count
Middle Aged
Prognosis
neutrophil‐to‐lymphocyte ratio
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Oncology
030220 oncology & carcinogenesis
Cohort
Carcinoma, Squamous Cell
Female
Mouth Neoplasms
Adult
Blood Platelets
medicine.medical_specialty
overall survival
lcsh:RC254-282
lymphocyte‐to‐monocyte ratio
03 medical and health sciences
Preoperative Care
medicine
Confidence Intervals
Humans
Radiology, Nuclear Medicine and imaging
Neutrophil to lymphocyte ratio
Oral Cavity Squamous Cell Carcinoma
Risk factor
Proportional Hazards Models
Retrospective Studies
business.industry
Cancer
Clinical Cancer Research
medicine.disease
Confidence interval
Surgery
Blood Cell Count
030104 developmental biology
Multivariate Analysis
business
Subjects
Details
- Language :
- English
- ISSN :
- 20457634
- Volume :
- 10
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Cancer Medicine
- Accession number :
- edsair.doi.dedup.....2f4aa6dccf752c0e9a0e0917a4ca36a7