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Effect of Artocarpus communis Extract on UVB Irradiation-Induced Oxidative Stress and Inflammation in Hairless Mice
- Source :
- International Journal of Molecular Sciences, Vol 14, Iss 2, Pp 3860-3873 (2013), International Journal of Molecular Sciences; Volume 14; Issue 2; Pages: 3860-3873, International Journal of Molecular Sciences
- Publication Year :
- 2013
- Publisher :
- MDPI AG, 2013.
-
Abstract
- Administration of antioxidants and anti-inflammatory agents is an effective strategy for preventing ultraviolet (UV) irradiation-induced skin damage. Artocarpus communis possesses several pharmacological activities, such as antioxidant, anticancer and anti-inflammation. However, the photoprotective activity of methanol extract of A. communis heartwood (ACM) in ultraviolet irradiation-induced skin damage has not yet been investigated. The present study was performed using ultraviolet absorption, histopathological observation, antioxidant and anti-inflammation assays to elucidate the mechanism of the photoprotective activity of ACM. Our results indicated that ACM displayed a UVA and UVB absorption effect and then effectively decreased scaly skin, epidermis thickness and sunburn cells during ultraviolet irradiation in hairless mice. ACM not only decreased ultraviolet irradiation-mediated oxidative stress, including lowering the overproduction of reactive oxygen species and lipid peroxidation (p < 0.05), but also reduced the levels of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α) and interleukin 1β. Additionally, ACM can decrease the synthesis of cytosolic phospholipase A2, cyclooxygenase, inducible nitric oxide synthase and vascular cell adhesion molecular-1 via inhibiting TNF-α-independent pathways (p < 0.05) in UVB-mediated inflammation and formation of sunburn cells. Consequently, we concluded that ACM extract has a photoprotective effect against UVB-induced oxidative stress and inflammation due to its sunscreen property, and its topical formulations may be developed as therapeutic and/or cosmetic products in further studies.
- Subjects :
- Antioxidant
antioxidant
medicine.medical_treatment
Inflammation
Pharmacology
medicine.disease_cause
Catalysis
Article
Inorganic Chemistry
Lipid peroxidation
lcsh:Chemistry
chemistry.chemical_compound
ultraviolet
medicine
Artocarpus communis
anti-inflammation
photoprotective
Physical and Theoretical Chemistry
Sunburn
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
chemistry.chemical_classification
Reactive oxygen species
biology
integumentary system
Chemistry
Organic Chemistry
General Medicine
medicine.disease
Computer Science Applications
Hairless
Nitric oxide synthase
Biochemistry
lcsh:Biology (General)
lcsh:QD1-999
biology.protein
medicine.symptom
Oxidative stress
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 14
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....2f47fa9881c4a28bada4b1df3d5c3b5f