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Crimean Congo hemorrhagic fever serosurvey in humans for identifying high-risk populations and high-risk areas in the endemic state of Gujarat, India
- Source :
- BMC Infectious Diseases, BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-8 (2019)
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Background Crimean Congo Hemorrhagic Fever (CCHF) is a highly infectious zoonotic disease of humans transmitted by Hyalomma ticks. Earlier studies have shown CCHF seroprevalence in livestock throughout India, yet sporadic outbreaks have been recorded mostly from the Gujarat state of India since 2011. Occupational vulnerability to CCHF for animal handlers, veterinarians, abattoir workers, and healthcare workers has been documented. The current study was planned to determine the seroprevalence of CCHF with an intention to identify the high -risk population and high -risk areas from Gujarat state, India. Methods Based on the socio-clinical data, the human population of Gujarat was divided into eight categories viz. A: CCHF affected person/house/close contact, B: Neighborhood contacts, C: Animal handlers, D: General population, E: Farmers, F: Abattoir workers, G: Veterinarian, H: Healthcare workers. A total of 4978 human serum samples were collected from 33 districts of Gujarat during year 2015, 2016 and 2017. All the samples were screened for the presence of anti-CCHFV IgG using indigenously developed anti-CCHFV IgG ELISA. Univariate regression analysis was performed to recognize significant risk factors for CCHF seropositivity. Results Twenty-five serum samples were found to be positive with an overall CCHF human seropositivity of 0.5% (95% CI 0.30–0.74%). Gender predisposition to CCHF prevalence was observed in males (OR: 2.80; p-value: 0.020). The risk for seropositivity increased sevenfold when a person was in contact or neighbor with a CCHF case (OR 7.02; p-value
- Subjects :
- Male
0301 basic medicine
Crimean–Congo hemorrhagic fever
Prevalence
Disease Outbreaks
Ticks
0302 clinical medicine
Blood serum
Risk Factors
Seroepidemiologic Studies
Zoonoses
Serosurvey
030212 general & internal medicine
Child
Aged, 80 and over
education.field_of_study
biology
Middle Aged
Infectious Diseases
Child, Preschool
Hemorrhagic Fever Virus, Crimean-Congo
ELISA
Female
Research Article
Human
Gujarat
Adult
Livestock
Adolescent
030106 microbiology
Population
India
Crimean Congo hemorrhagic fever
Enzyme-Linked Immunosorbent Assay
Tick
lcsh:Infectious and parasitic diseases
Young Adult
03 medical and health sciences
Environmental health
medicine
Animals
Humans
Seroprevalence
lcsh:RC109-216
education
Aged
business.industry
Infant, Newborn
Infant
Outbreak
biology.organism_classification
medicine.disease
Agricultural Workers' Diseases
Hemorrhagic Fever, Crimean
business
Hyalomma
Subjects
Details
- ISSN :
- 14712334
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- BMC Infectious Diseases
- Accession number :
- edsair.doi.dedup.....2f4682a9f3fcf20cb267ae66bd521852