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CCL22 is a biomarker of cartilage injury and plays a functional role in chondrocyte apoptosis
- Source :
- Cytokine. 115:32-44
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Background Osteoarthritis (OA) is one of the leading causes of disability worldwide. Previous history of knee injury is a significant risk factor for OA. It has been established that low-level chronic inflammation plays a pivotal role in the onset and pathogenesis of OA. The primary aim of this research was to determine if a history of knee joint injury is associated with systemic inflammation. A secondary aim was to determine if systemic inflammation is related to knee pain and joint structure. Methods Differences in serum cytokine association networks, knee joint structural changes (MRI), and self-reported pain (i.e., Knee Injury and Osteoarthritis Outcome Score Pain subscale, KOOSPAIN and Intermittent and Constant Osteoarthritis Pain score, ICOAP) between individuals who had sustained a youth (aged 15–26 years) sport-related knee injury 3–10 years previously and age- and sex-matched controls were examined. Proteins of interest were also examined in an OA rat model. Results Cytokine association networks were found to differ significantly between study groups, yet no significant associations were found between networks and KOOSPAIN or MRI-defined OA. A group of cytokines (MCP1/CCL2, CCL22 and TNFα) were differentially associated with other cytokines between study groups. In a pre-clinical rat OA model, serum CCL22 levels were associated with pain (r = 0.255, p = 0.045) and structural changes to the cartilage. CCL22 expression was also observed in human OA cartilage and furthermore, CCL22 induced apoptosis of isolated human chondrocytes. Discussion These results suggest that CCL22 may be an early factor in the onset/pathogenic process of cartilage degeneration and/or related to pain OA.
- Subjects :
- Adult
Cartilage, Articular
Male
0301 basic medicine
Oncology
medicine.medical_specialty
Adolescent
Knee Joint
Immunology
Pain
Apoptosis
Inflammation
Knee Injuries
Osteoarthritis
Systemic inflammation
Biochemistry
Chondrocyte
Young Adult
03 medical and health sciences
Chondrocytes
0302 clinical medicine
Internal medicine
Animals
Humans
Immunology and Allergy
Medicine
Knee
Molecular Biology
Chemokine CCL22
Tumor Necrosis Factor-alpha
business.industry
Cartilage
Hematology
Osteoarthritis, Knee
medicine.disease
Rats
030104 developmental biology
medicine.anatomical_structure
Knee pain
030220 oncology & carcinogenesis
Cytokines
Biomarker (medicine)
Female
medicine.symptom
business
Biomarkers
Subjects
Details
- ISSN :
- 10434666
- Volume :
- 115
- Database :
- OpenAIRE
- Journal :
- Cytokine
- Accession number :
- edsair.doi.dedup.....2f44ca36116ecf637d4741b8cbb69894