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Update on ocular gene therapy and advances in treatment of inherited retinal diseases and exudative macular degeneration
- Source :
- Current Opinion in Ophthalmology. 27:268-273
- Publication Year :
- 2016
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2016.
-
Abstract
- Purpose of review The purpose of this article is to provide an update on ocular gene therapy and discuss current active clinical trials. Recent findings The main target for ocular gene therapy involves the retinal pigment epithelium or photoreceptors. The most common method to deliver viral vectors to these cells includes intravitreal injection, subretinal injection, or access from the suprachoroidal space. Recombinant adeno-associated virus and lentivirus can be engineered to maximize gene delivery to specific targets. There are several clinical trials currently aimed at treating inherited and retinal diseases with gene therapy via viral vectors. Summary Recent advances in gene therapy have allowed for a better understanding of inherited and proliferative retinal diseases. New techniques have been developed to improve delivery of viral vectors to their cellular targets. There are currently multiple active clinical trials involving gene therapy underway with promising preliminary results.
- Subjects :
- 0301 basic medicine
Genetic enhancement
Genetic Vectors
Gene delivery
Bioinformatics
Viral vector
Macular Degeneration
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Retinal Diseases
medicine
Animals
Humans
Clinical Trials as Topic
Retinal pigment epithelium
Gene therapy of the human retina
biology
business.industry
Retinal
Genetic Therapy
General Medicine
Macular degeneration
biology.organism_classification
medicine.disease
Ophthalmology
030104 developmental biology
medicine.anatomical_structure
chemistry
Lentivirus
030221 ophthalmology & optometry
business
Subjects
Details
- ISSN :
- 10408738
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Ophthalmology
- Accession number :
- edsair.doi.dedup.....2f231e1967ea2c6ce069575bf56199ac