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Flavors of Flaviviral RNA Structure: towards an Integrated View of RNA Function from Translation through Encapsidation
Flavors of Flaviviral RNA Structure: towards an Integrated View of RNA Function from Translation through Encapsidation
- Source :
- Bioessays
- Publication Year :
- 2019
- Publisher :
- John Wiley and Sons Inc., 2019.
-
Abstract
- For many viruses, RNA is the holder of genetic information and serves as the template for both replication and translation. While host and viral proteins play important roles in viral decision‐making, the extent to which viral RNA (vRNA) actively participates in translation and replication might be surprising. Here, the focus is on flaviviruses, which include common human scourges such as dengue, West Nile, and Zika viruses, from an RNA‐centric viewpoint. In reviewing more recent findings, an attempt is made to fill knowledge gaps and revisit some canonical views of vRNA structures involved in replication. In particular, alternative views are offered on the nature of the flaviviral promoter and genome cyclization, and the feasibility of refining in vitro‐derived models with modern RNA probing and sequencing methods is pointed out. By tracing vRNA structures from translation through encapsidation, a dynamic molecule closely involved in the self‐regulation of viral replication is revealed.<br />Flaviviral RNA is replete with unique secondary and tertiary structures that participate in the dynamic regulation of viral replication through cyclization, polymerase binding, switching between translation and replication, and host interaction and adaptation. Here, an attempt is made to summarize and also re‐examine the current understanding of how viral RNA (vRNA) functions at the molecular level.
- Subjects :
- Untranslated region
RNA, Untranslated
viruses
RNA-dependent RNA polymerase
Computational biology
Genome, Viral
Dengue virus
Biology
Viral Nonstructural Proteins
medicine.disease_cause
Genome
viral RNA genome
General Biochemistry, Genetics and Molecular Biology
RNA‐dependent RNA polymerase (RdRp)
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Nucleic acid structure
Promoter Regions, Genetic
3' Untranslated Regions
030304 developmental biology
0303 health sciences
Base Sequence
Flavivirus
Virus Assembly
Review Essay
RNA
Dengue virus (DENV)
Translation (biology)
host–virus interactions
Prospects & Overviews
Viral replication
nonstructural protein 5 (NS5)
Protein Biosynthesis
RNA, Viral
untranslated region (UTR)
5' Untranslated Regions
030217 neurology & neurosurgery
flaviviruses
Subjects
Details
- Language :
- English
- ISSN :
- 15211878 and 02659247
- Volume :
- 41
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Bioessays
- Accession number :
- edsair.doi.dedup.....2f1c23fb5ac7cd4b8747ed7ea5ed64b3