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Coronary artery stenosis-related perfusion ratio using dynamic computed tomography myocardial perfusion imaging: a pilot for identification of hemodynamically significant coronary artery disease
- Source :
- Cardiovascular Intervention and Therapeutics
- Publication Year :
- 2019
- Publisher :
- Springer Japan, 2019.
-
Abstract
- The purpose of this study was to evaluate the feasibility of the stenosis-related quantitative perfusion ratio (QPR) for detecting hemodynamically significant coronary artery disease (CAD). Twenty-seven patients were retrospectively enrolled. All patients underwent dynamic myocardial computed tomography perfusion (CTP) and coronary computed tomography angiography (CTA) before invasive coronary angiography (ICA) measuring the fractional flow reserve (FFR). Coronary lesions with FFR ≤ 0.8 were defined as hemodynamically significant CAD. The myocardial blood flow (MBF) was calculated using dynamic CTP data, and CT-QPR was calculated as the CT-MBF relative to the reference CT-MBF. The stenosis-related CT-MBF and QPR were calculated using Voronoi diagram-based myocardial segmentation from coronary CTA data. The relationships between FFR and stenosis-related CT-MBF or QPR and the diagnostic performance of the stenosis-related CT-MBF and QPR were evaluated. Of 81 vessels, FFR was measured in 39 vessels, and 20 vessels (51%) in 15 patients were diagnosed as hemodynamically significant CAD. The stenosis-related CT-QPR showed better correlation (r = 0.70, p r = 0.56, p p
- Subjects :
- Male
medicine.medical_specialty
Myocardial ischemia
Computed Tomography Angiography
Computed tomography
Fractional flow reserve
Coronary Artery Disease
030204 cardiovascular system & hematology
Coronary Angiography
Myocardial blood flow
030218 nuclear medicine & medical imaging
Coronary artery disease
03 medical and health sciences
Myocardial perfusion imaging
0302 clinical medicine
Predictive Value of Tests
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Aged
Retrospective Studies
medicine.diagnostic_test
Receiver operating characteristic
business.industry
Coronary Stenosis
Hemodynamics
Myocardial Perfusion Imaging
Interventional radiology
General Medicine
Blood flow
Middle Aged
medicine.disease
Fractional Flow Reserve, Myocardial
Cardiology
Feasibility Studies
Original Article
Female
Cardiology and Cardiovascular Medicine
business
Tomography, X-Ray Computed
Perfusion
circulatory and respiratory physiology
Subjects
Details
- Language :
- English
- ISSN :
- 18684297 and 18684300
- Volume :
- 35
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Intervention and Therapeutics
- Accession number :
- edsair.doi.dedup.....2f197d6e8786b05697d06a419c314cc0