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Serum carotenoid depletion follows first-order kinetics in healthy adult women fed naturally low carotenoid diets
- Source :
- The Journal of nutrition. 131(8)
- Publication Year :
- 2001
-
Abstract
- Dietary intakes of carotenoids are highly variable in human populations as are serum carotenoid concentrations. However, there are few controlled data relating carotenoid intake to concentration. Most of the data that are available are from measurements of the absorption and decay of large pharmacologic doses of carotenoids, and are therefore of unknown physiologic relevance. Our objective was to determine the half-life (t(1/2)) of the most abundant carotenoids in blood serum from healthy adult women living under controlled conditions. As part of two carotenoid isotopic studies, we measured serum concentrations of beta-carotene, alpha-carotene, lutein, zeaxanthin, beta-cryptoxanthin and lycopene in 19 healthy young adult women that were fed controlled low carotenoid diets for approximately 10 wk. All other nutrients (vitamins A, E and C) were provided at 100-150% of the 1989 U.S. recommended dietary allowance levels. Exercise and activities were controlled throughout the studies to simulate usual activity patterns. Carotenoid concentrations were measured by reversed-phase HPLC. Serum carotenoid concentration decreases during depletion followed first-order kinetics. The half-lives determined in decreasing order were as follows: lutein (76 d) > alpha-carotene (45 d) = beta-cryptoxanthin (39 d) = zeaxanthin (38 d) = beta-carotene (37 d) > lycopene (26 d). Half-lives were unrelated to physical or demographic characteristics such as body mass, body fat, racial background or age in these relatively homogeneous groups. Carotenoids decreased by similar first-order mechanisms, although the rates differed for individual carotenoids.
- Subjects :
- Adult
Lutein
Adolescent
Medicine (miscellaneous)
Biology
Xanthophylls
chemistry.chemical_compound
Blood serum
Lycopene
Double-Blind Method
Zeaxanthins
Humans
Food science
Carotenoid
Exercise
Chromatography, High Pressure Liquid
Cryptoxanthins
chemistry.chemical_classification
Nutrition and Dietetics
organic chemicals
food and beverages
beta Carotene
Carotenoids
Diet
Zeaxanthin
Biochemistry
chemistry
Dietary Reference Intake
Xanthophyll
Cryptoxanthin
Female
Half-Life
Subjects
Details
- ISSN :
- 00223166
- Volume :
- 131
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- The Journal of nutrition
- Accession number :
- edsair.doi.dedup.....2ef87650a2211d6d68336c98126cfc3e