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Comparison of the trometamol-balanced solution with two other crystalloid solutions for fluid resuscitation of a rat hemorrhagic model
- Source :
- Journal of Veterinary Science
- Publication Year :
- 2020
- Publisher :
- The Korean Society of Veterinary Science, 2020.
-
Abstract
- Currently, the optimal resuscitation fluid remains debatable. Therefore, in the present study, we designed a trometamol-balanced solution (TBS) for use as a resuscitation fluid for hemorrhagic shock. Hemorrhagic shock was induced in 18 male Wistar-Kyoto rats, which were assigned to normal saline (NS), Ringer's solution (RS), and TBS groups. During the hemorrhagic state, their hemodynamic parameters were recorded using an Abbott i-STAT analyzer with the CG4+ cartridge (for pH, pressure of carbon dioxide, pressure of oxygen, total carbon dioxide, bicarbonate, base excess, oxygen saturation, and lactate), the CG6+ cartridge (for sodium, potassium, chloride, blood glucose, blood urea nitrogen, hematocrit, and hemoglobin), and enzyme-linked immunosorbent assay kits (calcium, magnesium, creatinine, aspartate aminotransferase, alanine aminotransferase, bilirubin, and albumin). Similar trends were found for the parameters of biochemistries, electrolytes, and blood gas, and they revealed no significant changes after blood withdrawal-induced hemorrhagic shock. However, the TBS group showed more effective ability to correct metabolic acidosis than the NS and RS groups. TBS was a feasible and safe resuscitation solution in this study and may be an alternative to NS and RS for resuscitation in hemorrhagic shock patients without liver damage.
- Subjects :
- Male
Resuscitation
medicine.medical_treatment
hemorrhagic model
Buffers
Shock, Hemorrhagic
Hematocrit
Resuscitation fluid
Emergency & Critical Care
Random Allocation
medicine
normal saline
Animals
Tromethamine
Saline
Blood urea nitrogen
General Veterinary
medicine.diagnostic_test
Chemistry
Albumin
Metabolic acidosis
Ringer's solution
Crystalloid Solutions
medicine.disease
Rats
Disease Models, Animal
Anesthesia
Fluid Therapy
Original Article
Base excess
Saline Solution
Subjects
Details
- ISSN :
- 1976555X and 1229845X
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Science
- Accession number :
- edsair.doi.dedup.....2ef608cc515b5e040ccde53e69b9e450