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Diffuse Corneal Clouding in Siblings With Fetal Alcohol Syndrome
- Source :
- American Journal of Ophthalmology. 115:484-493
- Publication Year :
- 1993
- Publisher :
- Elsevier BV, 1993.
-
Abstract
- Three of four siblings born to parents with a history of heavy alcohol abuse had bilateral diffusely cloudy corneas at birth. These three siblings, who had mild systemic features of fetal alcohol syndrome, underwent corneal transplantations, and their specimens were examined by light and electron microscopy. Histologically, the alterations in Bowman's layer ranged from thickening to total loss. There were varying degrees of corneal stromal edema. The unique pathologic feature in the corneas was the anomaly of the anterior banded zone of Descemet's membrane, which was either absent, poorly formed, or thinned in the central and peripheral cornea. The corneal endothelium was attenuated or multilayered. The diffuse clouding and the range of histologic abnormalities in the corneas might be related to the maternal alcohol abuse.
- Subjects :
- Male
Corneal endothelium
medicine.medical_specialty
medicine.medical_treatment
Eye disease
Fetal alcohol syndrome
Alcohol abuse
Cornea
Corneal Transplantation
Corneal Opacity
Ophthalmology
medicine
Humans
Corneal transplantation
Corneal stromal edema
business.industry
Infant
Anatomy
medicine.disease
eye diseases
Pedigree
medicine.anatomical_structure
Fetal Alcohol Spectrum Disorders
Child, Preschool
Female
sense organs
business
Complication
Subjects
Details
- ISSN :
- 00029394
- Volume :
- 115
- Database :
- OpenAIRE
- Journal :
- American Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....2edd752427232340989f3f2e9b46396a