HIV-Exposed, Uninfected Infants in Uganda Experience Poorer Growth and Body Composition Trajectories than HIV-Unexposed Infants

OBJECTIVES: To determine if HIV-exposed and -uninfected (HEU) infants whose mothers received Option B + have higher odds of experiencing suboptimal growth trajectories than HIV-unexposed uninfected (HUU) infants. METHODS: Anthropometric measures were taken on 238 infants (HEU = 86) at 1 week and 1,3,6,9, and 12 months. Latent class growth mixture modeling was used to develop trajectories for length-for-age z-scores, weight-for-length z-scores, MUAC, sum of skinfolds, and arm fat area. Multinomial logistic models were built to predict odds of class membership by HIV and food security status, controlling for socioeconomic factors. RESULTS: HEU infants had greater odds of being in the shortest two classes (OR = 4.30, P = 0.01 and OR = 10.70, P