CD4+ Regulatory T Lymphocytes Prevent Impaired Cerebral Blood Flow in Angiotensin II‐Induced Hypertension

Background Immune cells are key regulators of the vascular inflammatory response characteristic of hypertension. In hypertensive rodents, regulatory T lymphocytes (Treg, CD 4 + CD 25 + ) prevented vascular injury, cardiac damage, and endothelial dysfunction of mesenteric arteries. Whether Treg modulate the cerebrovascular damage induced by hypertension is unknown. Methods and Results C57 BL /6 mice were perfused with angiotensin II (Ang II ; 1000 ng/kg per minute) for 14 days and adoptive transfer of 3×10 5 CD 4 + CD 25 + T cells was performed via 2 intravenous injections. Control mice received a sham surgery and PBS . Treg prevented Ang II ‐induced neurovascular uncoupling ( P P II ‐induced neurovascular uncoupling ( P II ( P P P Conclusions Treg prevent impaired cerebrovascular responses in Ang II ‐induced hypertension. The neuroprotective effects of Treg involve the modulation of inflammation in the brain and periphery.