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A Gag-Pol/Env-Rev SIV239 DNA vaccine improves CD4 counts, and reduce viral loads after pathogenic intrarectal SIV(mac)251 challenge in rhesus Macaques
- Source :
- ResearcherID
- Publication Year :
- 2003
-
Abstract
- DNA vaccines are an important vaccine approach for many infectious diseases including human immunodeficiency virus (HIV). Recently, there have been exciting results reported for plasmid vaccination in pathogenic SHIV model systems. In these studies, plasmid vaccines supplemented by IL-2 Ig cytokine gene adjuvants or boosted by recombinant MVA vectors expressing relevant SIV and HIV antigens prevented CD4(+) T-cell loss and lowered viral loads following pathogenic challenge. However, similar results have not been reported in a direct pathogenic macaque challenge model. Here we report on a study of the ability of a multiplasmid SIV DNA vaccine in a pathogenic SIV251 rhesus mucosal challenge study. We observed that pGag/Pol+pEnv/Rev plasmid vaccines could not prevent SIV infection; however, vaccinated animals exhibited significant improvement in control of viral challenge compared to control animals. Furthermore, vaccinated animals exhibited protection against CD4(+) T-cell loss.
- Subjects :
- viruses
Simian Acquired Immunodeficiency Syndrome
Biology
medicine.disease_cause
DNA vaccination
medicine
Vaccines, DNA
Animals
General Veterinary
General Immunology and Microbiology
SAIDS Vaccines
Vaccination
Public Health, Environmental and Occupational Health
Gene Products, env
Simian immunodeficiency virus
Viral Load
biology.organism_classification
Virology
Macaca mulatta
CD4 Lymphocyte Count
Fusion Proteins, gag-pol
Infectious Diseases
HIV Antigens
Gene Products, rev
Immunology
Lentivirus
Molecular Medicine
Viral disease
Viral load
Subjects
Details
- ISSN :
- 0264410X
- Volume :
- 21
- Issue :
- 7-8
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....2ec0c3edea6a6eee52d3aebe415641d8