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Association Between Use of Dipeptidyl Peptidase-4 Inhibitors and the Risk of Acute Kidney Injury: A Nested Case-Control Study
- Source :
- Mayo Clinic Proceedings. 91:867-872
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Objective To examine the risk of acute kidney injury (AKI) in a nationwide cohort of patients with type 2 diabetes initiating dipeptidyl peptidase-4 (DPP-4) inhibitors. Patients and Methods This nested case-control study of a cohort of adult DPP-4 inhibitor users with type 2 diabetes who were hospitalized for AKI between January 1, 2010, and December 31, 2013, was conducted using Taiwan's National Health Insurance Research Database. Each AKI case was matched with one control subject according to duration of follow-up, age, sex, urbanization level, monthly income, comorbidity severity, and well-known predisposing factors for AKI. Odds ratios (ORs) for AKI were calculated according to current, recent, or past use of DPP-4 inhibitors. Results A total of 6752 cases with AKI and 6752 matched controls were analyzed. The exposure prevalence of DPP-4 inhibitor use in the previous year was higher among patients with AKI (adjusted OR, 1.20; 95% CI, 1.05-1.36; P =.006). In a stratified analysis, the association was significant for current DPP-4 inhibitor use (adjusted OR, 1.26; 95% CI, 1.08-1.48; P =.004), but not for recent or past use. Conclusion In this large contemporary cohort, DPP-4 inhibitor users had an increased risk of AKI development compared with nonusers. Further research is warranted to investigate the mechanism underlying this association.
- Subjects :
- Male
medicine.medical_specialty
Databases, Factual
Taiwan
Administration, Oral
Comorbidity
Type 2 diabetes
030204 cardiovascular system & hematology
Risk Assessment
03 medical and health sciences
0302 clinical medicine
Internal medicine
Odds Ratio
medicine
Humans
Hypoglycemic Agents
Longitudinal Studies
030212 general & internal medicine
Intensive care medicine
Aged
Dipeptidyl-Peptidase IV Inhibitors
business.industry
Acute kidney injury
Case-control study
General Medicine
Odds ratio
Acute Kidney Injury
medicine.disease
Diabetes Mellitus, Type 2
Case-Control Studies
Nested case-control study
Cohort
Female
Risk assessment
business
Subjects
Details
- ISSN :
- 00256196
- Volume :
- 91
- Database :
- OpenAIRE
- Journal :
- Mayo Clinic Proceedings
- Accession number :
- edsair.doi.dedup.....2ebd280635c0fed7e4ad37f6b78395f5