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Insulin resistance and potential modulators of ovarian reserve in young reproductive-aged women with obesity and type 1 diabetes
- Source :
- Gynecological Endocrinology. 37:823-830
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- Both obesity and diabetes play a significant role in reproductive disorders in women and insulin resistance (IR) is a confirmedWe recruited 32 female youths: 14 of them presented with T1D (14.6 ± 2.6 years) and 18 with obesity (15.1 ± 2.6 years). The control group included 20 age-matched normal weight females. Each patient underwent physical examination and hormonal assessment. AMH, kisspeptin and adiponectin levels were also measured. IR was calculated as the homeostasis model assessment for insulin resistance (HOMA-IR) and the glucose disposal rate (eGDR) in patients with obesity and with T1D, respectively.adiponectin and kisspeptin levels were significantly different into groups (IR displays a relationship with adiponectin and kisspeptin in young reproductive-aged women with obesity and T1D. Interventions to correct IR in adolescents could be part of an early approach to prevent reproductive disorders and to promote factors associated with longevity in adult women.
- Subjects :
- Anti-Mullerian Hormone
medicine.medical_specialty
Adolescent
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Body Mass Index
Young Adult
03 medical and health sciences
0302 clinical medicine
Endocrinology
Insulin resistance
Kisspeptin
Internal medicine
Diabetes mellitus
medicine
Humans
Obesity
Ovarian Reserve
Ovarian reserve
Kisspeptins
Type 1 diabetes
030219 obstetrics & reproductive medicine
Adiponectin
business.industry
Obstetrics and Gynecology
medicine.disease
Diabetes Mellitus, Type 1
Female
Insulin Resistance
business
Biomarkers
Subjects
Details
- ISSN :
- 14730766 and 09513590
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Gynecological Endocrinology
- Accession number :
- edsair.doi.dedup.....2eab975e11764ac807de0f500dfe3af4