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Hippocampal serotonin depletion is related to the presence of generalized tonic-clonic seizures, but not to psychiatric disorders in patients with temporal lobe epilepsy
- Source :
- Epilepsy research. 111
- Publication Year :
- 2014
-
Abstract
- Summary Objective Previous studies suggest that concentration of serotonin ([5-HT]) plays a pathogenic role in various types of epilepsy inhibiting seizures. However, most have not considered the clinical variables of epilepsy, and all of these studies included small and heterogeneous samples with refractory epilepsy, regardless of etiology. In this work, we measured [5-HT]s in hippocampal tissues from a large series of patients with refractory temporal lobe epilepsy caused by hippocampal sclerosis who underwent epilepsy surgery and evaluated the relationship between [5HT] and epilepsy-related clinical variables and psychiatric disorders. Methods We included 44 patients with refractory unilateral TLE-HS who underwent surgical treatment for epilepsy. Hippocampal samples were collected, and serotonin concentrations were measured with high-pressure liquid chromatography (HPLC). Results Lower [5-HT]s were correlated with a history of GTC seizures (Student's t -test: p 0.041). There were no differences in [5-HT]s according to the other clinical variables and the presence of psychiatric disorders. Significance Our findings demonstrated that serotonin depletion in the hippocampus play an important role in some aspects of the severity of epilepsy (i.e., the presence of GTC seizures) in a homogeneous sample of patients with refractory temporal lobe epilepsy determined by hippocampal sclerosis, but not with the presence of psychiatric disorders.
- Subjects :
- Adult
Male
medicine.medical_specialty
Serotonin
Adolescent
Hippocampus
Hippocampal formation
Temporal lobe
Epilepsy
Young Adult
Seizures
medicine
Humans
Epilepsy surgery
Psychiatry
Child
Chromatography, High Pressure Liquid
Aged
Hippocampal sclerosis
Depression
Middle Aged
medicine.disease
Neurology
Epilepsy, Temporal Lobe
Psychotic Disorders
Etiology
Female
Neurology (clinical)
Psychology
Subjects
Details
- ISSN :
- 18726844
- Volume :
- 111
- Database :
- OpenAIRE
- Journal :
- Epilepsy research
- Accession number :
- edsair.doi.dedup.....2ea6b4bb631de6a7575f1d38754f44c0