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Clinical Significance of Serum Hemeoxygenase-1 as a New Biomarker for the Patients with Interstitial Pneumonia
- Source :
- Canadian Respiratory Journal, Vol 2018 (2018), Canadian Respiratory Journal
- Publication Year :
- 2018
- Publisher :
- Hindawi, 2018.
-
Abstract
- Background. Serum hemeoxygenase-1 (HO-1) has been proposed to be a biomarker of lung disease activity and prognosis. The present study aimed at evaluating whether HO-1 could be a useful marker for evaluating disease activity and predicting prognosis in patients with interstitial pneumonia (IP). Materials and Methods. Serum HO-1 levels of newly diagnosed or untreated patients with IP were measured at hospitalization. We evaluated the relationships between serum HO-1 and other serum biomarkers, high resolution CT (HRCT) findings, and hospital mortality. Results. Twenty-eight patients with IP, including 14 having an acute exacerbation (AE) and 14 not having an AE, were evaluated. The patients having an AE had significantly higher HO-1 levels than those not having an AE (53.5 ng/mL vs. 24.1 ng/mL; p<0.001), and the best cut-off level to discriminate between having an AE or not having an AE was 41.6 ng/mL. Serum HO-1 levels were positively correlated with serum levels of surfactant protein-D (r=0.66, p<0.001) and the ground glass opacity score (calculated from HRCT; r=0.40, p=0.036). Patients who subsequently died in hospital had presented with significantly higher HO-1 levels than those who did not die in hospital (64.8 ng/mL vs. 32.0 ng/mL; p=0.009). Conclusion. Serum HO-1 may serve as a useful biomarker for detecting AE or predicting hospital mortality in patients with IP.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Exacerbation
Article Subject
Pulmonary Fibrosis
Newly diagnosed
Hospital mortality
030204 cardiovascular system & hematology
Gastroenterology
Ground-glass opacity
Hemeoxygenase 1
03 medical and health sciences
Diseases of the respiratory system
0302 clinical medicine
Internal medicine
Humans
Medicine
Interstitial pneumonia
Clinical significance
Hospital Mortality
Aged
Aged, 80 and over
RC705-779
business.industry
Middle Aged
Prognosis
Idiopathic Pulmonary Fibrosis
Hospitalization
030228 respiratory system
Disease Progression
Biomarker (medicine)
Female
medicine.symptom
Tomography, X-Ray Computed
business
Heme Oxygenase-1
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 11982241
- Database :
- OpenAIRE
- Journal :
- Canadian Respiratory Journal
- Accession number :
- edsair.doi.dedup.....2ea3839aea85466d9324869c9e1bd3a8
- Full Text :
- https://doi.org/10.1155/2018/7260178