Back to Search Start Over

Inhibition of growth of Leishmania donovani promastigotes by newly synthesized 1,3,4-thiadiazole analogs

Authors :
Yunus M. Siddiqui
Ahmed A. Al-Qahtani
Ola A. El-Sayed
Adnan A. Bekhit
Hassan Y. Aboul-Enein
Mohammed N. Al-Ahdal
Source :
Saudi Pharmaceutical Journal. (3):227-232
Publisher :
King Saud University. Production and hosting by Elsevier B.V.

Abstract

Leishmania donovani, the causative agent of visceral leishmaniasis, is transmitted by sand flies and replicates intracellularly in their mammalian host cells. The emergence of drug-resistant strains has hampered efforts to control the spread of the disease worldwide. Forty-four 1,3,4-thiadiazole derivatives and related compounds were tested in vitro for possible anti-leishmanial activity against the promastigotes of L. donovani. Micromolar concentrations of these agents were used to study the inhibition of multiplication of L. donovani promastigotes. Seven compounds were identified with potential antigrowth agents of the parasite. Compound 4a was the most active at 50μM followed by compound 3a. These compounds could prove useful as a future alternative for the control of visceral leishmaniasis.

Details

Language :
English
ISSN :
13190164
Issue :
3
Database :
OpenAIRE
Journal :
Saudi Pharmaceutical Journal
Accession number :
edsair.doi.dedup.....2ea0ec8cb026a065fd9b07788393a8d9
Full Text :
https://doi.org/10.1016/j.jsps.2009.08.005