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Inulin as a Delivery Vehicle for Targeting Colon-Specific Cancer
- Source :
- Current Drug Delivery. 17:651-674
- Publication Year :
- 2020
- Publisher :
- Bentham Science Publishers Ltd., 2020.
-
Abstract
- Natural polysaccharides, as well as biopolymers, are now days widely developed for targeting colon cancer using various drug delivery systems. Currently, healing conformations are being explored that can efficiently play a multipurpose role. Owing to the capability of extravagance colonic diseases with the least adverse effects, biopolymers for site specific colon delivery have developed an increased curiosity over the past decades. Inulin (INU) was explored for its probable application as an entrapment material concerning its degradation by enzymes in the colonic microflora and its drug release behavior in a sustained and controlled manner. INU is a polysaccharide and it consists of 2 to 1 linkage having an extensive array of beneficial uses such as a carrier for delivery of therapeutic agents as an indicative/investigative utensil or as a dietary fiber with added well-being aids. In the main, limited research, as well as information, is available on the delivery of therapeutic agents using inulin specifically for colon cancer because of its capability to subsist in the stomach’s acidic medium. This exceptional steadiness and robustness properties are exploited in numerous patterns to target drugs securely for the management of colonic cancer, where they effectively act and kills colonic tumor cells easily. In this review article, recent efforts and inulin-based nano-technological approaches for colon cancer targeting are presented and discussed.
- Subjects :
- Dietary Fiber
Colon
Colorectal cancer
Inulin
Administration, Oral
Pharmaceutical Science
02 engineering and technology
Colon specific
Global Burden of Disease
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Antineoplastic Combined Chemotherapy Protocols
Humans
Medicine
Prodrugs
Intestinal Mucosa
Drug Carriers
business.industry
Delivery vehicle
Cancer
021001 nanoscience & nanotechnology
medicine.disease
Gastrointestinal Microbiome
Review article
chemistry
030220 oncology & carcinogenesis
Colonic Neoplasms
Drug delivery
Cancer research
Dietary fiber
0210 nano-technology
business
SEER Program
Subjects
Details
- ISSN :
- 15672018
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Current Drug Delivery
- Accession number :
- edsair.doi.dedup.....2e9e5da4bda1063797da9b920180f059