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Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide
- Source :
- Thorax
- Publication Year :
- 2021
- Publisher :
- BMJ Publishing Group, 2021.
-
Abstract
- Reduction of the risk of asthma attacks is a major goal of current asthma management. We propose to derive a risk scale predicting asthma attacks based on the blood eosinophil count and exhaled nitric oxide (FeNO). Biomarker-stratified trial-level attack rates were extracted and pooled from the control arms of the Novel START, CAPTAIN, QUEST, Benralizumab Phase 2b, PATHWAY, STRATOS 1–2 and DREAM trials (n=3051). These were used to derive rate ratios and the predicted asthma attack rate for different patient groups. The resultant prototype risk scale shows potential to predict asthma attacks, which may be prevented by anti-inflammatory treatment.
- Subjects :
- Pulmonary and Respiratory Medicine
medicine.medical_specialty
Asthma attack
Nitric Oxide
Brief Communication
Asthma management
Leukocyte Count
chemistry.chemical_compound
Internal medicine
medicine
Humans
Derivation
allergic lung disease
Blood eosinophil
Asthma
business.industry
asthma epidemiology
clinical epidemiology
asthma
medicine.disease
Benralizumab
respiratory tract diseases
Eosinophils
respiratory measurement
Breath Tests
exhaled airway markers
chemistry
Exhalation
Exhaled nitric oxide
eosinophil biology
pulmonary eosinophilia
Blood eosinophils
business
Biomarkers
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Thorax
- Accession number :
- edsair.doi.dedup.....2e906ed79be8ce4873e1bbf928e691ed
- Full Text :
- https://doi.org/10.1136/thoraxjnl-2021-217325