Back to Search Start Over

Quality of Life After Fractional Flow Reserve–Guided PCI Compared With Coronary Bypass Surgery

Authors :
William F, Fearon
Frederik M, Zimmermann
Victoria Y, Ding
Jo M, Zelis
Zsolt, Piroth
Giedrius, Davidavicius
Samer, Mansour
Rajesh, Kharbanda
Nikolaos, Östlund-Papadogeorgos
Keith G, Oldroyd
Olaf, Wendler
Michael J, Reardon
Y Joseph, Woo
Alan C, Yeung
Nico H J, Pijls
Bernard, De Bruyne
Manisha, Desai
Mark A, Hlatky
Source :
Circulation. 145:1655-1662
Publication Year :
2022
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2022.

Abstract

Background: Previous studies have shown that quality of life improves after coronary revascularization more so after coronary artery bypass grafting (CABG) than after percutaneous coronary intervention (PCI). This study aimed to evaluate the effect of fractional flow reserve guidance and current generation, zotarolimus drug-eluting stents on quality of life after PCI compared with CABG. Methods: The FAME 3 trial (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) is a multicenter, international trial including 1500 patients with 3-vessel coronary artery disease who were randomly assigned to either CABG or fractional flow reserve–guided PCI. Quality of life was measured using the European Quality of Life–5 Dimensions (EQ-5D) questionnaire at baseline and 1 and 12 months. The Canadian Cardiovascular Class angina grade and working status were assessed at the same time points and at 6 months. The primary objective was to compare EQ-5D summary index at 12 months. Secondary end points included angina grade and work status. Results: The EQ-5D summary index at 12 months did not differ between the PCI and CABG groups (difference, 0.001 [95% CI, –0.016 to 0.017]; P =0.946). The trajectory of EQ-5D during the 12 months differed ( P Conclusions: In the FAME 3 trial, quality of life after fractional flow reserve–guided PCI with current generation drug-eluting stents compared with CABG was similar at 1 year. The rate of significant angina was low in both groups and not significantly different. The trajectory of improvement in quality of life was significantly better after PCI, as was working status in those Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02100722.

Details

ISSN :
15244539 and 00097322
Volume :
145
Database :
OpenAIRE
Journal :
Circulation
Accession number :
edsair.doi.dedup.....2e8c06df2836158f2aaddef1055336eb