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Translating preclinical approaches into human application
- Publication Year :
- 2012
- Publisher :
- Elsevier, 2012.
-
Abstract
- In recent decades, several novel approaches of spinal cord repair have revealed promising findings in animal models. However, for a successful translation of these into a clinical trial in humans the specific conditions pertaining to human spinal cord injuries (SCI) have to be appreciated. Firstly, transection of the spinal cord is commonly applied in animal models, whereas spinal cord contusion is the predominant type of injury in humans, and generally leads to more extensive injury in two to three spinal cord segments. Secondly, the quadrupedal organization of locomotion in animals and the more complex autonomic functions in humans challenge the translation of animal behavior into recovery from human SCI. Thirdly, so far, no adequate animal model has been developed to resemble spastic movement disorder in human SCI. Fourthly, the extensive damage to spinal motor neurons and nerve roots in human cervical and thoracolumbar in spine trauma is but little addressed in current translational studies. This damage has direct implications for rehabilitation and repair strategies. Fifthly, there is increasing evidence for a neuronal dysfunction below the level of the lesion in chronic complete SCI. The relevance of this dysfunction for a regeneration-inducing treatment needs to be investigated. Lastly, an approach to facilitate an appropriate reconnection of regenerating tract fibers by functional training in the postacute stage has yet to be confirmed.
- Subjects :
- Rehabilitation
Nerve root
business.industry
medicine.medical_treatment
610 Medicine & health
Spinal cord
Lesion
Clinical trial
2728 Neurology (clinical)
Animal model
medicine.anatomical_structure
Spinal cord contusion
2808 Neurology
Spastic
Medicine
10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center
medicine.symptom
business
Neuroscience
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....2e8b5cbc90a34ea1b27708f6b7fe65c5