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Sequence variants in the human 25-hydroxyvitamin D3 1-?-hydroxylase (CYP27B1) gene are not associated with prostate cancer risk
- Source :
- The Prostate. 53:175-178
- Publication Year :
- 2002
- Publisher :
- Wiley, 2002.
-
Abstract
- BACKGROUND 1,25-dihydroxyvitamin D3 has been shown to have antiproliferative properties on normal and neoplastic prostatic cells. 25-hydroxyvitamin D3 1-α-hydroxylase, the enzyme that catalyzes the final step of vitamin D synthesis, converting 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3, is expressed in the prostate. METHODS The human 25-hydroxyvitamin D3 1-α-hydroxylase gene (CYP27B1) was resequenced in a case/control panel consisting of 64 individuals (48 Caucasians and 16 African Americans), with equal numbers of hereditary prostate cancer cases, sporadic cases, and unaffected controls. Three frequent single nucleotide polymorphisms (SNPs) were genotyped in 245 prostate cancer cases and 222 controls. RESULTS Six noncoding SNPs were identified in the CYP27B1 gene. No significant difference was found in allele and genotype frequencies between sporadic cases and unaffected controls for the three genotyped SNPs. CONCLUSION This study suggests that the CYP27B1 gene does not play a major role as a prostate cancer susceptibility gene. Prostate 53: 175–178, 2002. © 2002 Wiley-Liss, Inc.
- Subjects :
- Male
medicine.medical_specialty
Urology
25-Hydroxyvitamin D3 1-alpha-hydroxylase
Single-nucleotide polymorphism
Biology
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Prostate cancer
Prostate
Internal medicine
Genotype
polycyclic compounds
medicine
Humans
Genetic Predisposition to Disease
Allele
Gene
Alleles
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Prostatic Neoplasms
DNA, Neoplasm
Sequence Analysis, DNA
Middle Aged
medicine.disease
Genotype frequency
Endocrinology
medicine.anatomical_structure
Oncology
Case-Control Studies
Cancer research
Subjects
Details
- ISSN :
- 10970045 and 02704137
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- The Prostate
- Accession number :
- edsair.doi.dedup.....2e89d1713d8015a36157bb39f9de9375