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Repair of DNA double-strand breaks by mammalian alternative end-joining pathways
- Source :
- Journal of Biological Chemistry. 293:10536-10546
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Alternative end-joining (a-EJ) pathways, which repair DNA double-strand breaks (DSBs), are initiated by end resection that generates 3' single strands. This reaction is shared, at least in part, with homologous recombination but distinguishes a-EJ from the major nonhomologous end-joining pathway. Although the a-EJ pathways make only a minor and poorly understood contribution to DSB repair in nonmalignant cells, there is growing interest in these pathways, as they generate genomic rearrangements that are hallmarks of cancer cells. Here, we review and discuss the current understanding of the mechanisms and regulation of a-EJ pathways, the role of a-EJ in human disease, and the potential utility of a-EJ as a therapeutic target in cancer.
- Subjects :
- 0301 basic medicine
Genome instability
DNA End-Joining Repair
DNA damage
DNA polymerase
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine
Animals
Humans
DNA Breaks, Double-Stranded
Disease
Homologous Recombination
Molecular Biology
chemistry.chemical_classification
DNA ligase
Thematic Minireviews
biology
Cancer
Cell Biology
medicine.disease
Cell biology
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
Cancer cell
biology.protein
Homologous recombination
DNA
Signal Transduction
Subjects
Details
- ISSN :
- 00219258
- Volume :
- 293
- Database :
- OpenAIRE
- Journal :
- Journal of Biological Chemistry
- Accession number :
- edsair.doi.dedup.....2e88f0970c68b626f17168afb4078f15