Updated in silico prediction methods for fractions absorbed and absorption rate constants of 372 disparate chemicals for use in physiologically based pharmacokinetic models for estimating internal concentrations in rats

Authors :: Koichiro, Adachi
Makiko, Shimizu
Hiroshi, Yamazaki
Source :: The Journal of Toxicological Sciences. 47:453-456
Publication Year :: 2022
Publisher :: Japanese Society of Toxicology, 2022.
Abstract: Physiologically based pharmacokinetic (PBPK) modeling has the potential to estimate internal chemical exposures. Algorithms for predicting the input parameters for PBPK modeling, such as absorption rate constants (k

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