Survey of germline variants in cancer-associated genes in young adults with colorectal cancer

Authors :: Joanne P. Young
Amanda R. Townsend
Nicola K. Poplawski
Jennifer E. Hardingham
Jinghua Feng
Eric Smith
Arne Zibat
Yun Li
Timothy J. Price
Gökhan Yigit
Christian Müller
Wendy Uylaki
Reger R. Mikaeel
Mehgan Horsnell
Bernd Wollnik
Yoko Tomita
Gonzalo Tapia Rico
Silke Kaulfuß
Mikaeel, Reger R
Young, Joanne P
Li, Yun
Smith, Eric
Horsnell, Mehgan
Uylaki, Wendy
Tapia Rico, Gonzalo
Poplawski, Nicola K
Hardingham, Jennifer E
Tomita, Yoko
Townsend, Amanda R
Feng, Jinghua
Zibat, Arne
Kaulfuß, Silke
Müller, Christian
Yigit, Gökhan
Wollnik, Bernd
Price, Timothy J
Source :: Genes, chromosomescancerREFERENCES. 61(2)
Publication Year :: 2021
Abstract: Colorectal cancer (CRC) incidence in young adults is rising. Identifying genetic risk factors is fundamental for the clinical management of patients and their families. This study aimed to identify clinically significant germline variants among young adults with CRC. Whole-exome sequencing data of blood-derived DNA from 133 unrelated young CRC patients (

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