Back to Search
Start Over
Chick oviduct progesterone receptor binding of 15 beta, 17-dihydroxyprogesterone and its analogues
- Source :
- Steroids. 43(2)
- Publication Year :
- 1984
-
Abstract
- We have tested derivatives of progesterone obtained by fermentation with Aspergillus giganteus for relative binding affinity for the progesterone receptor of chick oviduct. Our studies show that hydroxyl and oxo substitutents at C-11 and C-15 of progesterone significantly decrease the hormone's affinity for the progesterone receptor. The loss in affinity on introduction of a C-15 hydroxyl in 17-hydroxyprogesterone is restored by acetylation to 15β-acetoxy-17 hydroxyprogesterone. The latter compound may have some potential as an in vivo agent.
- Subjects :
- medicine.medical_specialty
Progesterone receptor binding
Clinical Biochemistry
Oviducts
Biology
Biochemistry
Binding, Competitive
Structure-Activity Relationship
Endocrinology
Cytosol
In vivo
Internal medicine
Progesterone receptor
medicine
Hydroxyprogesterones
Animals
Molecular Biology
Progesterone
Pharmacology
Organic Chemistry
Kinetics
Aspergillus
Acetylation
Oviduct
Hydroxyprogesterone
Fermentation
Female
Receptors, Progesterone
Hormone
Subjects
Details
- ISSN :
- 0039128X
- Volume :
- 43
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Steroids
- Accession number :
- edsair.doi.dedup.....2e7457005193bf4cbdda75de7a275e89