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Risk factors for measles infection in 0–7 month old children in China after the 2010 nationwide measles campaign: A multi-site case–control study, 2012–2013
- Source :
- Vaccine
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Introduction Endemic measles persists in China, despite >95% reported coverage of two measles-containing vaccine doses and nationwide campaign that vaccinated more than 100 million children in 2010. We performed a case–control study in six Chinese provinces during January 2012 through June 2013 to identify risk factors for measles infection among children aged 0–7 months. Methods Children with laboratory-confirmed measles were neighborhood matched with three controls. We interviewed parents of case and control infants on potential risk factors for measles. Adjusted matched odds ratios (mOR) and 95% confidence intervals (CIs) were calculated by multivariable conditional logistic modeling. We calculated attributable fractions for risk factors that could be interpreted as causal. Results Eight hundred thirty cases and 2303 controls were enrolled. In multivariable analysis, male sex (mOR 1.6 [1.3, 2.0]), age 5–7 months (mOR 3.9 [3.0, 5.1]), migration between counties (mOR 2.3 [1.6, 3.4]), outpatient hospital visits (mOR 9.4 [6.6, 13.3]) and inpatient hospitalization (mOR 107.1 [48.8, 235.1]) were significant risk factors. The calculated attributable fractions for hospital visits was 43.1% (95% CI: 40.1, 47.5%) adjusted for age, sex and migration. Conclusions Hospital visitation was the largest risk factor for measles infection in infants. Improved hospital infection control practices would accelerate measles elimination in China.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
China
Case–control study
030231 tropical medicine
Population immunity
Measles
Article
Herd immunity
03 medical and health sciences
0302 clinical medicine
Immunology and Microbiology(all)
Medicine
Infection control
Humans
030212 general & internal medicine
Risk factor
General Veterinary
General Immunology and Microbiology
business.industry
Case-control study
Infant, Newborn
Measles elimination
Public Health, Environmental and Occupational Health
Infant
Odds ratio
medicine.disease
veterinary(all)
Confidence interval
Infectious Diseases
Risk factors
Case-Control Studies
Molecular Medicine
Female
business
Subjects
Details
- ISSN :
- 0264410X
- Volume :
- 34
- Issue :
- 51
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....2e726656f74992d9cf17f2bf7b2bb3f7
- Full Text :
- https://doi.org/10.1016/j.vaccine.2016.02.002