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Dietary glycemic index, glycemic load, and lung cancer risk: A case-control study in Los Angeles County
- Source :
- Cancer Epidemiol
- Publication Year :
- 2020
- Publisher :
- eScholarship, University of California, 2020.
-
Abstract
- Background Although there is some evidence of positive associations between both the glycemic index (GI) and glycemic load (GL) with cancer risk, the relationships with lung cancer risk remain largely unexplored. We evaluated the associations between GI and GL with lung cancer. Methods The analyses were performed using data from a population-based case-control study recruited between 1999 and 2004 in Los Angeles County. Dietary factors were collected from 593 incident lung cancer cases and 1026 controls using a modified food frequency questionnaire. GI and GL were estimated using a food composition table. Adjusted odds ratios (ORs) and 95 % confidence intervals (CI) were estimated using unconditional logistic regression adjusting for potential confounders. Results Dietary GI was positively associated with lung cancer (OR for upper vs. lower tertile = 1.62; 95 % CI: 1.17, 2.25). For histologic subtypes, positive associations were observed between GI and adenocarcinoma (OR for upper vs. lower tertile = 1.82; 95 % CI: 1.22, 2.70) and small cell carcinoma (OR for upper vs. lower tertile = 2.68; 95 % CI: 1.25, 5.74). No clear association between GL and lung cancer was observed. Conclusion These findings suggest that high dietary GI was associated with increased lung cancer risk, and the positive associations were observed for both lung adenocarcinoma and small cell lung carcinoma. Replication in an independent dataset is merited for a broader interpretation of our results.
- Subjects :
- Male
Lung adenocarcinoma
Cancer Research
Lung Neoplasms
Epidemiology
Gastroenterology
0302 clinical medicine
Risk Factors
Glycemic load
Glycemic index
Medicine
030212 general & internal medicine
Lung
Cancer
education.field_of_study
Lung Cancer
Glycemic Load
Middle Aged
Los Angeles
Oncology
030220 oncology & carcinogenesis
Public Health and Health Services
Female
Small Cell Lung Carcinoma
Adult
medicine.medical_specialty
Adolescent
Population
Oncology and Carcinogenesis
Small-cell carcinoma
Article
03 medical and health sciences
Young Adult
Internal medicine
Humans
Small cell lung carcinoma
Oncology & Carcinogenesis
Risk factor
Lung cancer
education
Aged
Nutrition
business.industry
Prevention
Odds ratio
medicine.disease
Glycemic Index
Case-Control Studies
business
Digestive Diseases
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Cancer Epidemiol
- Accession number :
- edsair.doi.dedup.....2e61a3eb1f8e6000194f5ea5bc19cb1a