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Platelet factor 4 regulates T cell effector functions in malignant pleural effusions
- Source :
- CANCER LETTERS, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, r-IIB SANT PAU: Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, Institut dInvestigació Biomèdica Sant Pau (IIB Sant Pau)
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Malignant pleural effusion (MPE) is defined as the presence of tumor cells in pleural fluid and it is a fatal complication of advanced lung adenocarcinoma (LAC). To understand the immune response to the tumor in MPE, we compared the concentration of immunomodulatory factors in MPE of LAC and pleural effusion of heart failure (HF) patients by ELISA, and the proliferation and cytotoxic phenotype of T cells stimulated in the presence of LAC and HF pleural fluids by cytometry. Platelet factor 4 (PF4), vascular endothelial growth factor (VEGF), transforming growth factor beta (TGF-beta) and P-selectin levels were higher in LAC than in HF pleural fluids. However, plasmatic PF4 and P-selectin levels were similar in LAC and HF. VEGF positively correlated with TGF-beta and sPD-L1 in LAC but not in HF pleural fluids. LAC pleural fluids also inhibited T lymphocyte proliferation and cytotoxicity and reduced IL-17 production. PF4 levels inversely correlated with T cell function. The high content of PF4 in MPE was associated with poor prognosis. Our findings suggest that an impaired response of T lymphocytes induced by PF4 provides a significant advantage for tumor progression.
- Subjects :
- Male
Vascular Endothelial Growth Factor A
0301 basic medicine
Cancer Research
Lung Neoplasms
Pleural effusion
T-Lymphocytes
T cell
T lymphocytes
Adenocarcinoma of Lung
Lymphocyte Activation
Platelet Factor 4
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Immune system
Transforming Growth Factor beta
Platelet-derived soluble factors
Humans
Medicine
Cytotoxic T cell
Malignant pleural effusion
Aged
Aged, 80 and over
Heart Failure
business.industry
Middle Aged
medicine.disease
Pleural Effusion, Malignant
respiratory tract diseases
Vascular endothelial growth factor
PF4
030104 developmental biology
medicine.anatomical_structure
Oncology
chemistry
Tumor progression
030220 oncology & carcinogenesis
Cancer research
Female
Lung cancer
business
MPE
Immunosuppression
Platelet factor 4
Subjects
Details
- ISSN :
- 03043835
- Volume :
- 491
- Database :
- OpenAIRE
- Journal :
- Cancer Letters
- Accession number :
- edsair.doi.dedup.....2e60f785f6dc5ac60e8cfc8b55441565
- Full Text :
- https://doi.org/10.1016/j.canlet.2020.06.014